Results 191 to 200 of about 1,034,896 (346)

Sex-Specific patterns of vulnerability to alcohol addiction-like behaviors in rats. [PDF]

open access: yesTransl Psychiatry
Borruto AM   +6 more
europepmc   +1 more source

Profiling Localized Immunomodulation and Drug Biodistribution within a Subcutaneous Vascularized Niche for Cell Transplantation

open access: yesAdvanced Science, EarlyView.
We studied how five common immunosuppressants behave when delivered directly to a transplant site instead of systemically. Using a vascularized implant for islet transplantation, we show that local delivery protects grafts, limits drug spread to the rest of the body, and produces distinct immune signatures.
Jocelyn Nikita Campa‐Carranza   +19 more
wiley   +1 more source

Oil‐Coated Nanoplastics Induce Rapid Membrane Disruption and Severe Intestinal Injury

open access: yesAdvanced Science, EarlyView.
Oil‐rich food contact dramatically amplifies MNP release from plastic takeout containers, producing oil‐coated nanoplastics with altered surface properties and rapid membrane‐disruptive effects. These particles cause severe intestinal barrier damage and immune dysfunction in mice, and risk modeling suggests that long‐term gastrointestinal burdens may ...
Ruwen Xie   +17 more
wiley   +1 more source

Disconnect between in vitro and in vivo efficacy of the MPS1 inhibitor NTRC 0066-0 against glioblastoma. [PDF]

open access: yesCell Oncol (Dordr)
de Gooijer MC   +11 more
europepmc   +1 more source

Implantable microchip: the futuristic controlled drug delivery system

open access: yesDrug Delivery, 2016
K. B. Sutradhar, Chandra Datta Sumi
semanticscholar   +1 more source

Adhesion‐Related Macrophages Regulate Metabolic Homeostasis Through CAV‐1 Dependency

open access: yesAdvanced Science, EarlyView.
Adipose tissue harbors a distinct macrophage subpopulation, termed adhesion‐related macrophages (ARMs), which stably adhere to adipocytes. In obesity, ARMs represent the major expanding macrophage subset. They acquire material from adipocytes and rely on Caveolin‐1 for sustained lipid handling.
Wanyu Hu   +23 more
wiley   +1 more source

Classification status of drugs generally used for self-medication in children: a targeted review of regulatory documents. [PDF]

open access: yesJ Pharm Policy Pract
Dinni Fauzia R   +4 more
europepmc   +1 more source

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