Results 251 to 260 of about 490,902 (326)
American Journal of Psychiatry, 1969 Common current practice is to prescribe psychotropic drugs so that a specified daily amount is administered in equally divided doses on a three to six times a day schedule. The authors contend that this procedure rests on no valid scientific basis.
A, Dimascio, R I, Shader
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Fixed-interval schedules for drug self-administration in the rat
Psychopharmacology, 1989 The practicality of using second-order fixed-interval schedules in studies of heroin reinforcement with rats was examined. Optimum rates of responding were obtained with a dose of 0.03 mg/kg/infusion and an interval duration of 3 min. In addition, schedules consisting of a only a single interval were shown to be practical, leading to response rates ...
W A, Corrigall, K M, Coen
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Progressive-ratio schedules of drug delivery in the analysis of drug self-administration: a review
Psychopharmacology, 1998 Drugs, like other reinforcers, can vary in their relative abilities to support operant responding. Considerable research has been designed to obtain useful measures of a given drug's or dose's "reinforcing efficacy" and to identify the ways in which a variety of behavioral and pharmacological variables impact these measures. Progressive-ratio schedules
D, Stafford, M G, LeSage, J R, Glowa
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Drug Self-Administration by Laboratory Animals: Control by Schedules of Reinforcement
Annual Review of Pharmacology and Toxicology, 1978 A common factor underlying all concepts of drug dependence is the persistent maintenance of behavior that leads to drug self-administration (I, 2). Early studies of drug self-administration by laboratory animals involved morphine and employed subjects that were made physiologically (physically) dependent by repeated injec tions prior to the initiation
R D, Spealman, S R, Goldberg
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, 1984 The influence of two differently constructed dose schedules and of two dissimilar administration routes on the subacute toxicity of the potential antiviral drug benzoxazolyl-2-formyl-S-ethyl-isothiosemicarbazone was investigated in mice. Administration of identical aliquots of the, route dependent, maximally tolerated, dose was found to cause no ...
R, Amlacher, H, Hoffmann
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Journal of Neuroscience Methods, 1996
Drug self-administration studies have recently employed progressive ratio (PR) schedules to examine psychostimulant and opiate reinforcement. This review addresses the technical, statistical, and theoretical issues related to the use of the PR schedule in self-administration studies in rats.
N R, Richardson, D C, Roberts
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Drug self-administration studies have recently employed progressive ratio (PR) schedules to examine psychostimulant and opiate reinforcement. This review addresses the technical, statistical, and theoretical issues related to the use of the PR schedule in self-administration studies in rats.
N R, Richardson, D C, Roberts
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Psychiatry and Clinical Neurosciences, 1984 Abstract: Bromperidol (4 or 12 mg per day) was administered to 18 newly admitted schizophrenics and 29 chronic schizophrenic inpatients once or four times a day and the two dose schedules were compared. The bromperidol levels in the four‐times‐a‐day group were significantly higher than those in the once‐a‐day group and the daily variation in the serum
Y, Fujii +6 more
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Second-order schedules of drug self-administration in animals
Psychopharmacology, 2002 On a second-order schedule, a subject responds according to one schedule (the unit schedule) for a brief presentation of a stimulus such as a light. Responding by the subject on this unit schedule is then reinforced according to another schedule of reinforcement.
Charles W, Schindler +2 more
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