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Wearable and implantable devices for drug delivery: Applications and challenges.
Biomaterials, 2022Poor adherence to drug dosing schedule is responsible for ∼50% of hospitalization cases. Most patients fail to adhere to a strict dosing schedule due to invasive drug administration, off-target toxicities, or medical conditions like dementia.
Abhinanda Kar +5 more
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Second-order schedules of drug self-administration in animals
Psychopharmacology, 2002On a second-order schedule, a subject responds according to one schedule (the unit schedule) for a brief presentation of a stimulus such as a light. Responding by the subject on this unit schedule is then reinforced according to another schedule of reinforcement.
Charles W, Schindler +2 more
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Drug self-administration studies
Behavioural Pharmacology, 2013Relative reinforcing effects of different ethanol and different cocaine doses were studied under concurrent independent fixed-ratio (FR) schedules and concurrent nonindependent FR schedules with rhesus monkeys. Nonindependent FR schedules differed from independent FR schedules in that responses on either side counted towards the FR requirements of two ...
Richard A, Meisch, Thomas H, Gomez
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Fixed-interval schedules for drug self-administration in the rat
Psychopharmacology, 1989The practicality of using second-order fixed-interval schedules in studies of heroin reinforcement with rats was examined. Optimum rates of responding were obtained with a dose of 0.03 mg/kg/infusion and an interval duration of 3 min. In addition, schedules consisting of a only a single interval were shown to be practical, leading to response rates ...
W A, Corrigall, K M, Coen
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Drug Self-Administration by Laboratory Animals: Control by Schedules of Reinforcement
Annual Review of Pharmacology and Toxicology, 1978A common factor underlying all concepts of drug dependence is the persistent maintenance of behavior that leads to drug self-administration (I, 2). Early studies of drug self-administration by laboratory animals involved morphine and employed subjects that were made physiologically (physically) dependent by repeated injec tions prior to the initiation
R D, Spealman, S R, Goldberg
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Second-order schedules of intravenous drug self-administration in rhesus monkeys
Pharmacology Biochemistry and Behavior, 1977Lever-pressing behavior was generated and maintained in 3 rhesus monkeys by intravenous infusions of morphine or cocaine under a second-order schedule of reinforcement. Under this schedule, every tenth lever-press response (FR 10) during a fixed interval of time produced a 2 sec stimulus light.
J R, Sanchez-Ramos, C R, Schuster
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Progressive-ratio schedules of drug delivery in the analysis of drug self-administration: a review
Psychopharmacology, 1998Drugs, like other reinforcers, can vary in their relative abilities to support operant responding. Considerable research has been designed to obtain useful measures of a given drug's or dose's "reinforcing efficacy" and to identify the ways in which a variety of behavioral and pharmacological variables impact these measures. Progressive-ratio schedules
D, Stafford, M G, LeSage, J R, Glowa
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Effects of drugs on schedule-controlled behavior in rats during chronic haloperidol administration.
The Journal of Pharmacology and Experimental Therapeutics, 1985Dose-response curves for haloperidol, phencyclidine, morphine, meperidine and cimetidine were determined in rats trained under a multiple fixed-ratio 30, fixed-interval 5-min schedule of reinforcement. Haloperidol, morphine, meperidine and cimetidine decreased both fixed-ratio and fixed-interval rates of responding.
S K, Rastogi, D E, McMillan
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[Drug administration schedules in geriatric patients].
Medicina clinica, 1992In this study the prescription of drugs in an outpatients geriatric population was evaluated in terms of age and body weight.From a wide survey carried out on 500 geriatric outpatients, all the prescriptions corresponding to H-2 antagonists, digoxin, theophylline, bromazepam, diazepam, lorazepam and triazolam were analyzed. The patients studied were of
M L, Lucena González +5 more
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Естественные и технические науки, 2020
В данной статье рассматриваются результаты исследования по использованию гормональных препаратов в определённом режиме с целью контроля и управления репродуктивными функциями млекопитающих при искусственном осеменении на примере кроликов. The article discusses the results of hormonal drugs ...
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В данной статье рассматриваются результаты исследования по использованию гормональных препаратов в определённом режиме с целью контроля и управления репродуктивными функциями млекопитающих при искусственном осеменении на примере кроликов. The article discusses the results of hormonal drugs ...
openaire +1 more source