Results 281 to 290 of about 490,902 (326)

Measures of cocaine-seeking behavior using a multiple schedule of food and drug self-administration in rats

Drug and Alcohol Dependence, 1995
Animal models of human drug abuse measuring (i) cocaine-seeking behavior maintained by primary or secondary reinforcers, (ii) the time to extinction of cocaine-seeking behavior, and (iii) following extinction, reinstatement of operant responding resulting in presentation of a cocaine-associated stimulus were developed in rats.
R, Weissenborn, M, Yackey, G F, Koob, F, Weiss   +3 more
openaire   +2 more sources

[Developing a dose-administration schedule for drug therapy in childhood].

Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde, 1983
For the application of a target concentration strategy for the assessment of dosage regimens pharmacokinetic parameters and their variances must be known. Since pharmacokinetic parameters like the elimination constant or the volume of distribution undergo considerable changes during the perinatal period until early childhood, the application of ...
O, Richter, D, Reinhardt, W, Stutzinger
openaire   +1 more source

Abuse liability of the anesthetic propofol: self-administration of propofol in rats under fixed-ratio schedules of drug delivery

Psychopharmacology, 2000
Previous reports suggest that propofol (PPF) may have abuse potential in humans. Hence, we hypothesized that PPF could reinforce self-administration behavior in other species. Positive reinforcing effects of PPF could be interpreted as an index of abuse liability.Acquisition and maintenance of i.v.
M G, LeSage, D, Stafford, J R, Glowa
openaire   +2 more sources

[Irinotecan: various administration schedules, study of drug combinations, phase I experience].

Bulletin du cancer, 1999
Irinotecan (CPT11) is a synthetic camptothecin-derived DNA topoisomerase I inhibitor. Based on phase I clinical trials, several schedules have been recommended for phase I studies including 350 mg/m2 every 3 weeks in Europe, 125 mg/m2 for 4 weeks every 6 weeks in the USA, and 100 mg/m2 weekly or delayed until recovery in case of grade > 2 toxicity in ...
V, Boige, E, Raymond, J P, Armand
openaire   +1 more source

[Comparative study of 2 drug administration schedules in the preparation of the intestine for colorectal surgery].

Revista paulista de medicina, 1982
W A, Klug, P, Capelhuchnick
openaire   +2 more sources

Optimized sequence of drug administration and schedule leads to improved dose delivery for gemcitabine and paclitaxel in combination: a phase I trial in patients with recurrent ovarian cancer

, 2006
Christopher Poole, Timothy Perren, Sulochana R. Gawande, Mona Ridderheim, James A. Cook, A. Jenkins, D. Roychowdhury   +6 more
openalex   +2 more sources

Scheduling of vincristine: drug accumulation and response of xenografts of childhood rhabdomyosarcoma determined by frequency of administration.

Cancer treatment reports, 1987
Vincristine (VCR) is an effective agent in the treatment of childhood rhabdomyosarcoma. Clinically, schedules differ in frequency of administration. To determine the influence of administration frequency, accumulation of VCR in xenografts of human rhabdomyosarcoma has been evaluated following administration of drug at 7- or 21-day intervals ...
J A, Houghton, W H, Meyer, P J, Houghton
openaire   +1 more source

Antibody–drug conjugates: Smart chemotherapy delivery across tumor histologies

Ca-A Cancer Journal for Clinicians, 2022
Paolo Tarantino, Roberto Carmagnani Pestana, Chiara Corti   +2 more
exaly  

The effects of nucleus accumbens core and shell lesions on intravenous heroin self-administration and the acquisition of drug-seeking behaviour under a second-order schedule of heroin reinforcement

, 2000
Daniel M. Hutcheson, John A. Parkinson, Trevor W. Robbins, Barry J. Everitt   +3 more
openalex   +1 more source

Clinical translation of long-acting drug delivery formulations

Nature Reviews Materials, 2022
Wei Li, Dennis Lee, Thomas R Tice
exaly