Results 41 to 50 of about 46,872 (243)
Abstract Background The rectosigmoid brake, characterised by retrograde cyclic motor patterns on high‐resolution colonic manometry, has been postulated as a contributor to the maintenance of bowel continence. Sacral neuromodulation (SNM) is an effective therapy for faecal incontinence, but its mechanism of action is unclear.
Anthony Y. Lin+7 more
wiley +1 more source
Suicide in Narcotic Drugs Dependents [PDF]
Background: The problem of addiction is one of the four global crises. These patients are more vulnerable to mental disorders. This study aimed to examine the risk of suicide in drug dependent patients.
Alireza Ghaffari Nejad+3 more
doaj
Durante o período de pós-comercialização, quando medicamentos são usados por grandes populações e por períodos de tempo maiores, eventos adversos (EA) inesperados podem ocorrer, o que pode alterar a relação risco-benefício dos medicamentos o suficiente ...
Felipe Vieira Duval+1 more
doaj +1 more source
Abstract Objective The risk of seizure following BNT162b2 and CoronaVac vaccinations has been sparsely investigated. This study aimed to evaluate this association. Method Patients who had their first seizure‐related hospitalization between February 23, 2021 and January 31, 2022, were identified in Hong Kong. All seizure episodes happening on the day of
Eric Yuk Fai Wan+11 more
wiley +1 more source
Evaluation of Transparency to Improve Good Governance in Pharmaceutical Regulatory Sector of Iran
Background: Improving good governance in the pharmaceutical sector is a valuable priority for improving access to essential medicines. Transparency as a means for good governance was the focus of this study.
Yasaman Herandi+3 more
doaj
Rational Design of Unsaturated, Thioether Ionizable Lipids for Enhanced In Vivo mRNA Delivery
Lipid nanoparticles (LNPs) have rapidly become the delivery system of choice for RNA therapeutics. Here, a rational design approach is taken to improve the effectiveness of LNPs based on an ionizable thioether lipid library. The incorporation of unsaturated tails and bulkier, hydrophobic head groups significantly enhances their functionality and ...
Eleni Samaridou+4 more
wiley +1 more source
Narcotics and Criminality [PDF]
"Livet efter gymnasiesärskolan" är en intervjuundersökning med två årgångar elever som tagit studenten 2012 och 2013 från något av de fem erbjudna nationella programmen på gymnasiesärskolan inom Jämtlands gymnasieförbund (JGY). Syftet med studien var att
Finestone, Harold
core +2 more sources
Mexico’s “ley de narcomenudeo” drug policy reform and the international drug control regime
It has been over half a century since the landmark Single Convention on Narcotic Drugs was adopted, for the first time unifying international drug policy under a single treaty aimed at limiting use, manufacture, trade, possession, and trafficking of ...
T. Mackey+5 more
semanticscholar +1 more source
The Locus Coeruleus‐Periaqueductal Gray GABAergic Projection Regulates Comorbid Pain and Depression
LC‐GABA neurons exhibit elevated activity to noxious and aversive stimuli in chronic pain, and their activation alleviates pain‐ and depression‐like behaviors. While LC‐GABA neurons target LC‐NA neurons and GABA and Glu neurons in the vlPAG, they modulate the pain responses of LC‐NA neurons but regulate pain‐ and depression‐like behaviors through their
Yuan Gao+7 more
wiley +1 more source
Chemical dependency: an occupational hazard in the field of Anaesthesia [PDF]
The medical personnel are vulnerable to substance abuse and dependence due to ready access to substance of abuse. Addiction is considered as an occupational hazard for those involved in the practice of anaesthesia for the same reason.
Ismail, Samina
core +1 more source