Results 41 to 50 of about 46,872 (243)

Faecal incontinence is associated with an impaired rectosigmoid brake and improved by sacral neuromodulation

open access: yesColorectal Disease, Volume 24, Issue 12, Page 1556-1566, December 2022., 2022
Abstract Background The rectosigmoid brake, characterised by retrograde cyclic motor patterns on high‐resolution colonic manometry, has been postulated as a contributor to the maintenance of bowel continence. Sacral neuromodulation (SNM) is an effective therapy for faecal incontinence, but its mechanism of action is unclear.
Anthony Y. Lin   +7 more
wiley   +1 more source

Suicide in Narcotic Drugs Dependents [PDF]

open access: yesAddiction and Health, 2012
Background: The problem of addiction is one of the four global crises. These patients are more vulnerable to mental disorders. This study aimed to examine the risk of suicide in drug dependent patients.
Alireza Ghaffari Nejad   +3 more
doaj  

O uso do Twitter como minerador de eventos adversos de medicamentos de combate à malária: o caso da doxiciclina

open access: yesCadernos de Saúde Pública, 2019
Durante o período de pós-comercialização, quando medicamentos são usados por grandes populações e por períodos de tempo maiores, eventos adversos (EA) inesperados podem ocorrer, o que pode alterar a relação risco-benefício dos medicamentos o suficiente ...
Felipe Vieira Duval   +1 more
doaj   +1 more source

Association between the risk of seizure and COVID‐19 vaccinations: A self‐controlled case‐series study

open access: yesEpilepsia, Volume 63, Issue 12, Page 3100-3110, December 2022., 2022
Abstract Objective The risk of seizure following BNT162b2 and CoronaVac vaccinations has been sparsely investigated. This study aimed to evaluate this association. Method Patients who had their first seizure‐related hospitalization between February 23, 2021 and January 31, 2022, were identified in Hong Kong. All seizure episodes happening on the day of
Eric Yuk Fai Wan   +11 more
wiley   +1 more source

Evaluation of Transparency to Improve Good Governance in Pharmaceutical Regulatory Sector of Iran

open access: yesJournal of Evidence Based Health Policy, Management & Economics, 2020
Background: Improving good governance in the pharmaceutical sector is a valuable priority for improving access to essential medicines. Transparency as a means for good governance was the focus of this study.
Yasaman Herandi   +3 more
doaj  

Rational Design of Unsaturated, Thioether Ionizable Lipids for Enhanced In Vivo mRNA Delivery

open access: yesAdvanced Healthcare Materials, EarlyView.
Lipid nanoparticles (LNPs) have rapidly become the delivery system of choice for RNA therapeutics. Here, a rational design approach is taken to improve the effectiveness of LNPs based on an ionizable thioether lipid library. The incorporation of unsaturated tails and bulkier, hydrophobic head groups significantly enhances their functionality and ...
Eleni Samaridou   +4 more
wiley   +1 more source

Narcotics and Criminality [PDF]

open access: yes, 1957
"Livet efter gymnasiesärskolan" är en intervjuundersökning med två årgångar elever som tagit studenten 2012 och 2013 från något av de fem erbjudna nationella programmen på gymnasiesärskolan inom Jämtlands gymnasieförbund (JGY). Syftet med studien var att
Finestone, Harold
core   +2 more sources

Mexico’s “ley de narcomenudeo” drug policy reform and the international drug control regime

open access: yesHarm Reduction Journal, 2014
It has been over half a century since the landmark Single Convention on Narcotic Drugs was adopted, for the first time unifying international drug policy under a single treaty aimed at limiting use, manufacture, trade, possession, and trafficking of ...
T. Mackey   +5 more
semanticscholar   +1 more source

The Locus Coeruleus‐Periaqueductal Gray GABAergic Projection Regulates Comorbid Pain and Depression

open access: yesAdvanced Science, EarlyView.
LC‐GABA neurons exhibit elevated activity to noxious and aversive stimuli in chronic pain, and their activation alleviates pain‐ and depression‐like behaviors. While LC‐GABA neurons target LC‐NA neurons and GABA and Glu neurons in the vlPAG, they modulate the pain responses of LC‐NA neurons but regulate pain‐ and depression‐like behaviors through their
Yuan Gao   +7 more
wiley   +1 more source

Chemical dependency: an occupational hazard in the field of Anaesthesia [PDF]

open access: yes, 2010
The medical personnel are vulnerable to substance abuse and dependence due to ready access to substance of abuse. Addiction is considered as an occupational hazard for those involved in the practice of anaesthesia for the same reason.
Ismail, Samina
core   +1 more source

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