Results 1 to 10 of about 79,767 (169)

Protein Spatial Structure Meets Artificial Intelligence: Revolutionizing Drug Synergy–Antagonism in Precision Medicine [PDF]

Advanced Science
Targeted drug design and development, as a core area of modern pharmaceutical research, critically depends on the assessment of protein site druggability as a fundamental component.
Anqi Lin, Chang Che, Aimin Jiang, Chang Qi, Antonino Glaviano, Zhijie Zhao, Zhirou Zhang, Zaoqu Liu, Ziyao Zhou, Quan Cheng, Shuofeng Yuan, Peng Luo   +11 more
doaj   +2 more sources

Membrane-camouflaged supramolecular nanoparticles for co-delivery of chemotherapeutic and molecular-targeted drugs with siRNA against patient-derived pancreatic carcinoma

Acta Pharmaceutica Sinica B, 2022
Pancreatic cancer remains one of the most lethal malignancies worldwide. The combination of the first-line standard agent gemcitabine (GEM) with the molecular-targeted drug erlotinib (Er) has emerged as a promising strategy for pancreatic cancer ...
Honglin Tang, Yanan Xue, Bowen Li, Xiaojie Xu, Fu Zhang, Jiajing Guo, Qijun Li, Tingting Yuan, Yuan Chen, Yubin Pan, Yuan Ping, Da Li   +11 more
doaj   +1 more source

Selective D3 receptor antagonism modulates neural response during negative emotional processing in substance dependence

Frontiers in Psychiatry, 2022
IntroductionNegative affective states contribute to the chronic-relapsing nature of addiction. Mesolimbic dopamine D3 receptors are well placed to modulate emotion and are dysregulated in substance dependence.
Ioanna A. Vamvakopoulou, Leon Fonville, Alexandra Hayes, John McGonigle, Rebecca Elliott, Karen D. Ersche, Karen D. Ersche, Remy Flechais, Csaba Orban, Anna Murphy, Dana G. Smith, Dana G. Smith, John Suckling, John Suckling, Eleanor M. Taylor, Bill Deakin, Trevor W. Robbins, Trevor W. Robbins, David J. Nutt, Anne R. Lingford-Hughes, Louise M. Paterson   +20 more
doaj   +1 more source

Decoding the Postulated Entourage Effect of Medicinal Cannabis: What It Is and What It Isn’t

Biomedicines, 2023
The ‘entourage effect’ term was originally coined in a pre-clinical study observing endogenous bio-inactive metabolites potentiating the activity of a bioactive endocannabinoid.
Catalina Christensen, Martin Rose, Claus Cornett, Morten Allesø   +3 more
doaj   +1 more source

Renal fibrosis due to multiple cisplatin treatment is exacerbated by kinin B1 receptor antagonism

Brazilian Journal of Medical and Biological Research, 2021
Cisplatin is a widely used chemotherapeutic drug, but its side effects are a major limiting factor. Nephrotoxicity occurs in one third of patients undergoing cisplatin treatment.
A. Budu, L.C. Freitas-Lima, A.C. de Arruda, M.S. Perilhão, J. Barrera-Chimal, R.C. Araújo, G.R. Estrela   +6 more
doaj   +1 more source

Ultrasound-sensitive siRNA-loaded nanobubbles fabrication and antagonism in drug resistance for NSCLC

Drug Delivery, 2022
Due to the lack of safe, effective, and gene-targeted delivery technology. In this study, we have prepared nanobubbles loaded PDLIM5 siRNA (PDLIM5siRNA-NBs) to investigate the transfection efficiency and their antagonism in drug resistance in combination
Chunhong Su, XiaoJun Ren, Fang Yang, Bin Li, Hao Wu, Hui Li, Fang Nie   +6 more
doaj   +1 more source

Identification of a novel specific small-molecule melanocortin-2-receptor antagonist

Endocrine Connections, 2022
The overproduction of adrenocorticotropic hormone (ACTH), in conditions such as Cushing’s disease and congenital adrenal hyperplasia (CAH), leads to significant morbidity.
Rachel Forfar, Mashal Hussain, Puneet Khurana, Jennifer Cook, Steve Lewis, Dillon Popat, David Jackson, Ed McIver, Jeff Jerman, Debra Taylor, Adrian JL Clark, Li F Chan   +11 more
doaj   +1 more source

Methionine Antagonizes para-Aminosalicylic Acid Activity via Affecting Folate Precursor Biosynthesis in Mycobacterium tuberculosis

Frontiers in Cellular and Infection Microbiology, 2018
para-Aminosalicylic acid (PAS) is a second-line anti-tubercular drug that is used for the treatment of drug-resistant tuberculosis (TB). PAS efficacy in the treatment of TB is limited by its lower potency against Mycobacterium tuberculosis relative to ...
Michael D. Howe, Shannon L. Kordus, Malcolm S. Cole, Allison A. Bauman, Courtney C. Aldrich, Anthony D. Baughn, Yusuke Minato   +6 more
doaj   +1 more source

From a Pathophysiological Concept to a New Drug

European Psychiatry, 2022
Although antipsychotics were discovered over fifty years ago, it took another decade until dopamine antagonism was demonstrated as central to their clinical effectiveness.
G. Németh
doaj   +1 more source

Basic principles of combination therapy: focus on drug-drug interaction

Кардиоваскулярная терапия и профилактика, 2021
The article is devoted to the issue of drug interactions in the combination regimens. Today, when drug therapy is the first-line approach for patients with noncommunicable diseases, and the world population ageing leads to an increase in the number of ...
S. Yu. Martsevich, Yu. V. Lukina, O. M. Drapkina   +2 more
doaj   +1 more source