Results 271 to 280 of about 176,678 (306)
Some of the next articles are maybe not open access.
Dopamine Antagonism and Antischizophrenic Potency of Neuroleptic Drugs
Nature New Biology, 1973IT has been argued1–4 that ability to block central dopamine receptors is related to the therapeutic potency of neuroleptic drugs in schizophrenia. Two lines of evidence favour this hypothesis. First, dopamine antagonism probably underlies the “extrapyramidal” or Parkinsonian side effects of neuroleptic drugs5, and such side effects are a frequent ...
T J, Crow, C, Gillbe
openaire +2 more sources
Sulpha drugs and its antagonism
The Indian Journal of Pediatrics, 1948From the above experimental studies, and from the actual records we conclude that there is no necessity of an inference of the role of p-amino benzoic acid in the bacterial metabolism and how it is antagonised by the sulpha drugs. On the other hand we come to this conclusion from the results of direct observation that bacteria utilises oxygen from ...
openaire +1 more source
Antagonism of drug-induced pulsus alternans in dogs
American Journal of Physiology-Legacy Content, 1960Pulsus alternans and pseudoalternans were produced in dogs anesthetized with pentobarbital by intravenous injections of moderate doses of one of several pharmacologic agents. Ventricular alternation was alleviated or abolished by a) drugs with positive inotropic action, b) drugs that reduced peripheral resistance, and c) drugs with antiarrhythmic ...
openaire +2 more sources
Qualitative Aspects of Drug Antagonism
1937The relation between chemical structure and pharmacological action is a subject of notorious difficulty. It may be said that there are scarcely any general rules discernible and that every cell-drug system appears to be a law unto itself. In the case of drugs which have sharply specific actions, it is common to find that the activity even of optical ...
openaire +1 more source
Quantitative Aspects of Drug Antagonism and of Drug Synergism
1937It was shown in the last chapter that, in populations of animals, changes in sensitivity to drugs can be produced by a wide variety of causes, and that in some cases variations in sensitivity occur for which the causes are unknown. It seems justifiable to assume that if the condition of organisms is altered by the administration of one drug, then this ...
openaire +1 more source
In vitro assessment of farnesoid X receptor antagonism to predict drug-induced liver injury risk
Archives of Toxicology, 2020Aaron Fullerton +2 more
exaly