EVALUATION OF SYNERGISTIC EFFECT OF THUJAORIENTALIS WITH CIPROFLOXACIN AGAINST ESCHERICHIA COLI
Pakistan Armed Forces Medical Journal, 2020 Objectives: To determine the antimicrobial effect of Thujaorientalis (TO) and ciprofloxacin alone against Escherichia Coli (E.Coli). To compare the combined antimicrobial effect of TO and ciprofloxacin against E. Coli.
Hajra Mateen +3 more
doaj
, 2007 Piperaquine is being developed as a long-acting component in artemisinin combination therapies. It was highly active in vitro and drug interaction studies showed that dihydroartemisinin combinations with piperaquine, chloroquine, and amodiaquine were ...
Adagu, Ipemida S +2 more
core +2 more sources
Increased expression of 5-hydroxytryptamine(2A/B) receptors in idiopathic pulmonary fibrosis: a rationale for therapeutic intervention [PDF]
, 2010 Background Idiopathic pulmonary fibrosis (IPF) has a poor prognosis and limited responsiveness to available treatments. It is characterised by epithelial cell injury, fibroblast activation and proliferation and extracellular matrix deposition ...
Amarie, Oana Veronica +8 more
core +1 more source
Curiouser and Curiouser: The Macrocyclic Lactone, Abamectin, Is also a Potent Inhibitor of Pyrantel/Tribendimidine Nicotinic Acetylcholine Receptors of Gastro-Intestinal Worms. [PDF]
PLoS ONE, 2016 Nematode parasites may be controlled with drugs, but their regular application has given rise to concerns about the development of resistance. Drug combinations may be more effective than single drugs and delay the onset of resistance.
Melanie Abongwa +3 more
doaj +1 more source
Cognitive impairment induced by delta9-tetrahydrocannabinol occurs through heteromers between cannabinoid CB1 and serotonin 5-HT2A receptors [PDF]
, 2015 Delta-9-tetrahydrocannabinol (THC), the main psychoactive compound of marijuana, induces numerous undesirable effects, including memory impairments, anxiety, and dependence.
A Busquets-Garcia +112 more
core +6 more sources
Molecular Plant-Microbe Interactions, 2014 ATP-binding cassette (ABC) transporters mediate active efflux of natural and synthetic toxicants and are considered to be important for drug tolerance in microorganisms.
Mukesh K. Dubey +2 more
doaj +1 more source
PLoS ONE, 2020 Excitotoxicity mediated by the N-methyl-D-aspartate receptor (NMDAR) is believed to be a primary mechanism of neuronal injury following stroke. Thus, many drugs and therapeutic peptides were developed to inhibit either the NMDAR at the cell surface or ...
Che-Wei Liu +5 more
doaj +1 more source
Artificial intelligence for drug discovery: Resources, methods, and applications
Molecular Therapy: Nucleic Acids, 2023 Conventional wet laboratory testing, validations, and synthetic procedures are costly and time-consuming for drug discovery. Advancements in artificial intelligence (AI) techniques have revolutionized their applications to drug discovery.
Wei Chen +3 more
doaj +1 more source
Serotonin reuptake inhibitors and cardiovascular disease [PDF]
, 2005 Selective serotonin re-uptake inhibiting drugs (SSRIs) are widely used for endogenous depression. In addition to depleting the nerve terminals of serotonin they also lower blood platelet serotonin levels.
Belcher, P.R. +2 more
core +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source