Results 131 to 140 of about 5,351,550 (365)
Molecular Oncology, EarlyView.Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé +7 more
wiley +1 more source
Era of faster FDA drug approval has also seen increased black-box warnings and market withdrawals.
Health Affairs, 2014 After approval, many prescription medications that patients rely on subsequently receive new black-box warnings or are withdrawn from the market because of safety concerns.
Cassie Frank +7 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Patient engagement involves actively including patients in healthcare decisions and research to ensure care and studies align with their needs. This approach improves outcomes, trust, and communication while fostering collaboration between patients and professionals.
Estela Cepeda +3 more
wiley +1 more source
Iatreia, 2018 Several malignant disorders of human tissues affect a large proportion of people in Colombia and worldwide, which has led to an increase in pharmacological treatments for these diseases, without the real benefit being clear to the patients who receive ...
Arango Vélez, Elkin Fernando +7 more
doaj +1 more source
The role of clinical trials in the Food and Drug Administration approval process for cardiovascular devices. [PDF]
, 1994 Wolf Sapirstein +2 more
openalex +1 more source
Regulating Access to Developmental Drugs for Terminally Ill Patients: Abigail Alliance v FDA [PDF]
This amicus brief was filed in support of the Abigail Alliance for Better Access to Developmental Drugs in their lawsuit to force the Food and Drug Administration to provide patient access to drugs for cancer and other life-threatening illnesses after ...
Calfee, John E. +4 more
core +1 more source
Technology Unbound: Will Funded Libertarianism Dominate the Future? [PDF]
, 2007 The panel decision in Abigail Alliance, which found a constitutional right to use certain medicines that have not received Food and Drug Administration approval, may not survive further review, but it already stands as an important signpost on the road ...
Goldberg, Steven
core +1 more source
Molecular Oncology, EarlyView.This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini +10 more
wiley +1 more source
FDA New Drug Approval Times, Prescription Drug User Fees, and R & D Spending [PDF]
FDA-approval times have declined significantly since the enactment of the Prescription Drug User Fee Act (PDUFA) in 1992. As a result, present value expected returns to pharmaceutical R&D have likely increased.
Golec, Joseph H. +3 more
core +1 more source