Current guidelines applicable for the approval of dermatological drugs
, 2002 A Zesch
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United States Food and Drug Administration Approval Summary: Bortezomib for the Treatment of Progressive Multiple Myeloma after One Prior Therapy [PDF]
, 2006 Robert C. Kane +3 more
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Hydrogen sulfide repairs testicular damage induced by heat stress in rats
FEBS Open Bio, EarlyView.Heat stress can cause testicular damage and affect fertility. We investigated the potential protective role of hydrogen sulfide (H2S) against heat stress‐induced testicular injury and observed that H2S donor NaHS can effectively restore testicular damage in rats by inhibiting inflammation and oxidative stress. Our results suggest that H2S might be used
Xinyu Guo +6 more
wiley +1 more source
Drug-loaded erythrocytes: on the road toward marketing approval
Drug Design, Development and Therapy, 2016 Vanessa Bourgeaux,1 José M Lanao,2 Bridget E Bax,3 Yann Godfrin11ERYTECH Pharma, Lyon, France; 2Department of Pharmacy and Pharmaceutical Technology, University of Salamanca, Salamanca, Spain; 3Cardiovascular and Cell Sciences Research Institute ...
Bourgeaux V, Lanao JM, Bax BE, Godfrin Y
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Re-examining our approach to the approval and use of new drugs [PDF]
, 2006 S. K. Lee
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FEBS Open Bio, EarlyView.Heterologous expression of membrane transporters in cultured cells is essential for functional characterization, but is sometimes limited by low activity. Our study compares the HDAC inhibitors butyrate, VPA and SAHA to enhance transport activity. We propose to replace butyrate by SAHA: it is equally effective, devoid of repulsive odor, costs less, and
Svenja Flögel +4 more
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An estimate of rate of deviation from NCCN guideline recommendations for central nervous system imaging in trials forming basis for drug approval in first line advanced non-small cell lung cancer (NSCLC). [PDF]
BMC Cancer, 2022 Sharp J, Prasad V.
europepmc +1 more source
Informing prospective research subjects of the influence of regulatory requirements for drug approval on the design of clinical trials in oncology [PDF]
, 2007 Maurie Markman
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Establishment and biological characterization of radioresistant colorectal cancer cell lines
FEBS Open Bio, EarlyView.Under ionizing radiation exposure, radiation‐sensitive cancer cells exhibit oxidative stress and DNA damage, while radiation‐resistant cancer cells exhibit strong antioxidant properties and DNA damage repair. Radiotherapy resistance is a major cause of recurrence and metastasis in colorectal cancer (CRC).
Tian‐Yin Qu +10 more
wiley +1 more source
Minimal Residual Disease as an Early Endpoint for Accelerated Drug Approval in Myeloma: A Roadmap. [PDF]
Blood Cancer DiscovLandgren O, Devlin SM.
europepmc +1 more source