Results 221 to 230 of about 5,351,550 (365)
Gene-silencing technology gets first drug approval after 20-year wait
Nature, 2018 Heidi Ledford
semanticscholar +1 more source
Molecular Oncology, EarlyView.Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho +11 more
wiley +1 more source
Drug approval system questioned in US and Canada [PDF]
, 2005 Laura Eggertson
openalex +1 more source
Molecular Oncology, EarlyView.Comprehensive cancer centre (CCCs) and CCCs of Excellence (CCCoE) integration in healthcare. Through outreach to surrounding community hospitals, CCCs enable wider access to top‐clinical cancer treatments and care, thereby facilitating the swift enrolment of patients into data‐rich clinical trials (PI‐initiated trials testing new concepts, drug ...
Anton Berns +4 more
wiley +1 more source
Predictors of orphan drug approval
Orphanet Journal of Rare Diseases, 2010 Heemstra Harald
doaj +1 more source
US drug companies will meet more than half the cost of drug approval
, 2002 D. Josefson
openalex +2 more sources
United States Food and Drug Administration Approval Summary: Bortezomib for the Treatment of Progressive Multiple Myeloma after One Prior Therapy [PDF]
, 2006 Robert C. Kane +3 more
openalex +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Current guidelines applicable for the approval of dermatological drugs
, 2002 A Zesch
openalex +1 more source
A Proposal for Radical Changes in the Drug-Approval Process [PDF]
, 2006 Alex Philchenkov
openalex +1 more source