Results 231 to 240 of about 1,536,180 (350)
PHP94 THE ROLE OF HEALTH-RELATED QUALITY OF LIFE DATA IN THE DRUG APPROVAL PROCESSES IN THE UNITED STATES AND EUROPE: A REVIEW OF GUIDANCE DOCUMENTS AND AUTHORIZATIONS OF MEDICINAL PRODUCTS FROM 2006 TO 2010 [PDF]
, 2011 Patrick Marquis +4 more
openalex +1 more source
FEBS Open Bio, EarlyView.In this research, a rat model of asthma was created using OVA, and polydatin served as an intervention. By inhibiting ferroautophagy mediated by NCOA4 and averting ferroptosis, polydatin has been demonstrated to reduce asthma. This work presents new ideas for investigating the mechanism of polydatin's ability to alleviate asthma, in addition to ...
Wei Li +5 more
wiley +1 more source
Despite surge in orphan drug designations, approvals still lag [PDF]
, 2011 Monica Heger
openalex +1 more source
FEBS Open Bio, EarlyView.Sphingoid base structures, the sphingolipid backbones, vary among species. We established yeast cells in which the native sphingoid base was replaced with plant‐type bases containing cis or trans double bonds. This is, to our knowledge, the first eukaryotic model mostly composed of sphingolipids containing cis‐unsaturated sphingoid base, providing a ...
Takashi Higuchi +5 more
wiley +1 more source
Regulatory Approval of Cancer Risk-Reducing (Chemopreventive) Drugs: Moving What We Have Learned into the Clinic [PDF]
, 2011 Frank L. Meyskens +9 more
openalex +1 more source
FEBS Open Bio, EarlyView.Statins, identified via the Comparative Toxicogenomics Database, promote monocytic differentiation and apoptosis in non‐APL AML cells by upregulating DPYSL2A through a KLF4‐dependent pathway. Mevalonate supplementation reversed these effects, indicating involvement of the mevalonate pathway.
Mina Noura +7 more
wiley +1 more source
Magnitude of effect and sample size justification in trials supporting anti-cancer drug approval by the US Food and Drug Administration. [PDF]
Sci RepNadler MB +5 more
europepmc +1 more source
Class of once-weekly diabetes drugs poised for approval [PDF]
, 2011 Hannah Waters
openalex +1 more source
Amyotrophic Lateral Sclerosis as a Multistep Process in the United States: A Population‐Based Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Amyotrophic lateral sclerosis (ALS) is a fatal, progressive neurodegenerative disease that typically results in death within 3–5 years from symptom onset. However, little is known about the environmental exposures, clinical aspects, or social determinants of health factors that may be associated with the disease.
Jasmine Berry +7 more
wiley +1 more source