Results 261 to 270 of about 4,926,176 (337)

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

An Analysis of New Drug Examination and Approval System of PRC

, 2008
Xiaopu Sun
openalex   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

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Use of Single-Arm Trials for US Food and Drug Administration Drug Approval in Oncology, 2002-2021.

JAMA Oncology, 2022
Importance Single-arm trials have allowed for transformative therapies to be made available to patients expeditiously. However, using single-arm trials to support drug approval presents several challenges that must be carefully considered ...
S. Agrawal, Shaily Arora, L. Amiri-Kordestani, R. A. de Claro, L. Fashoyin-Aje, N. Gormley, Tamy Kim, S. Lemery, Gautam U. Mehta, E. Scott, H. Singh, Shenghui Tang, M. Theoret, R. Pazdur, P. Kluetz, J. Beaver   +15 more
semanticscholar   +1 more source

Impact of Drug Approval Pathways for Paediatric Inflammatory Bowel Disease.

Journal of Crohn's & Colitis, 2021
BACKGROUND AND AIMS Timely access to approved medications is a priority in paediatric inflammatory bowel disease (IBD). To date, the timing of drug studies in paediatric IBD has been suboptimal with most studies conducted long after approval has been ...
E. Crowley, Christopher Ma, Marija Andic, B. Feagan, A. Griffiths, V. Jairath   +5 more
semanticscholar   +1 more source

Drug approvals

The Nurse Practitioner, 2009
Gary Laustsen, Fernando Carrillo, Jessica Johnson, Cynthia Smith   +3 more
  +9 more sources

Overall Survival, Progression-Free Survival, and Tumor Response Benefit Supporting Initial US Food and Drug Administration Approval and Indication Extension of New Cancer Drugs, 2003-2021

Journal of Clinical Oncology, 2022
PURPOSE Clinical trial evidence is routinely evaluated for initial drug approvals, yet the benefit of indication extensions remains uncertain. This study evaluates the clinical benefit supporting new cancer drugs' initial and supplemental US Food and ...
D. Michaeli, T. Michaeli
semanticscholar   +1 more source

Drug Approval and Drug Effectiveness

Annual Review of Clinical Psychology, 2014
Data on the efficacy and safety of psychiatric medicines should form the foundation of evidence-based treatment practices. The US Food and Drug Administration (FDA) reviews such data in determining whether to approve new treatments, and the published literature serves as a repository for evidence on treatment benefits and harms.
Glen I, Spielmans, Irving, Kirsch
openaire   +2 more sources

Approving new drugs

Science, 2017
As the Trump administration takes shape, there is much speculation as to what major changes will be made. A dominant theme of the Trump campaign was to cut through bureaucracy in Washington, D.C., thereby enhancing innovation and bringing new technology to Americans more quickly.
openaire   +2 more sources