Results 261 to 270 of about 776,039 (330)

The evolution of European Medicines Agency drug approval: the adaptive licensing. [PDF]

Eur J Hosp Pharm, 2016
Di Giorgio C, Adami S, Provenzani A, Bianchi S, D'Alessandro N, Polidori P.   +5 more
europepmc   +1 more source

Improper Selection of a Pre-specified Primary Dose–Response Analysis Delays Regulatory Drug Approval

, 2013
Jiang Liu, Pravin Jadhav, Yaning Wang, Jogarao Gobburu   +3 more
openalex   +2 more sources

Evaluation of the dose reduction effect of crystalline lens exposure in cone‐beam computed tomography with bismuth eye shield for image‐guided radiation therapy: An anthropomorphic phantom study

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract This study aimed to evaluate the dose‐exposure reduction effect of a crystalline lens with a bismuth eye shield using cone‐beam computed tomography (CBCT) for head image‐guided radiation therapy. The ocular surface dose of the head phantom (THRA‐1) is defined as a crystalline lens exposure dose and is measured using a radiophotoluminescence ...
Tatsuya Yoshida, Koji Sasaki, Yoshiyuki Kawasaki, Tomoki Hayakawa, Toshiyuki Kawadai, Takako Shibasaki   +5 more
wiley   +1 more source

From 2D to 3D gamma passing rate tolerance and action limits for patient‐specific quality assurance in volumetric‐modulated arc therapy

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Background Volumetric modulated arc therapy (VMAT) requires an accurate patient‐specific quality assurance (PSQA) program. In clinical practice, this is usually performed using the γ‐index and the two‐dimensional gamma passing rate (2D %GP). A three‐dimensional (3D) index incorporating the patient anatomy could be more useful for the 3D dose ...
Christos Zarros, George Patatoukas, Nikos Kollaros, Marina Chalkia, Andromachi Kougioumtzopoulou, Vasilios Kouloulias, Kalliopi Platoni   +6 more
wiley   +1 more source

Evaluation of daily residual pancreatic tumor motion for deep‐inspiration breath‐hold radiotherapy

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose Breath‐hold techniques are widely used in radiation therapy to minimize respiratory‐induced tumor or organ‐at‐risk motion. However, residual motion persists, necessitating a reliable daily evaluation method. Methods At our institution, fiducial markers serve as surrogates for target localization in pancreatic cancer treatment.
Weihua Mao, Binbin Wu, Kai Ding, Sarah Han‐Oh, Amol Narang   +4 more
wiley   +1 more source

Does dose calculation algorithm affect the dosimetric accuracy of synthetic CT for MR‐only radiotherapy planning in brain tumors?

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose This study compares the dosimetric accuracy of deep‐learning‐based MR synthetic CT (sCT) in brain radiotherapy between the Analytical Anisotropic Algorithm (AAA) and AcurosXB (AXB). Additionally, it proposes a novel metric to predict the dosimetric accuracy of sCT for individual post‐surgical brain cases.
Jeffrey C. F. Lui, Francis K. H. Lee, C. C. Law, James C. H. Chow   +3 more
wiley   +1 more source

Analysis of Control Arm Quality in Randomized Clinical Trials Leading to Anticancer Drug Approval by the US Food and Drug Administration.

JAMA Oncol, 2019
Hilal T, Sonbol MB, Prasad V.
europepmc   +1 more source

Modelling of a double‐scattering proton therapy nozzle using the FLUKA Monte Carlo code and analysis of linear energy transfer in patients treated for prostate cancer

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Background The dose‐averaged linear energy transfer (LETD) in proton therapy (PT) has in pre‐clinical studies been linked to the relative biological effectiveness (RBE) of protons. Until recently, the most common PT delivery method in prostate cancer has been double‐scattered PT, with LETD only available through dedicated Monte Carlo (MC ...
Rasmus Klitgaard, Lars Fredrik Fjæra, Camilla Hanquist Stokkevåg, Perry Johnson, Mark Artz, Nancy Price Mendenhall, Curtis Bryant, Ludvig Paul Muren   +7 more
wiley   +1 more source

A review of artificial intelligence in brachytherapy

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Artificial intelligence (AI) has the potential to revolutionize brachytherapy's clinical workflow. This review comprehensively examines the application of AI, focusing on machine learning and deep learning, in various aspects of brachytherapy.
Jingchu Chen, Richard L. J. Qiu, Tonghe Wang, Shadab Momin, Xiaofeng Yang   +4 more
wiley   +1 more source

Assessing HyperSight iterative CBCT for dose calculation in online adaptive radiotherapy for pelvis and breast patients compared to synthetic CT

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose/objectives Recent technological advancements have increased efficiency for clinical deliverability of online‐adaptive‐radiotherapy (oART). Previous cone‐beam‐computed‐tomography (CBCT) generations lacked the ability to provide reliable Hounsfield‐units (HU), thus requiring oART workflows to rely on synthetic‐CT (sCT) images derived ...
Jingwei Duan, Joel A. Pogue, Dennis N. Stanley, Sui Shen, Natalie N. Viscariello, Carlos E. Cardenas, Richard A. Popple, Joseph Harms   +7 more
wiley   +1 more source