Results 271 to 280 of about 1,536,180 (350)

Association of the ICH Score With Withdrawal of Life‐Sustaining Treatment Over a 10‐Year Period

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The intracerebral hemorrhage (ICH) score was developed to enhance provider communication and facilitate early severity assessment. We examined the association of the ICH score with mortality and withdrawal of life‐sustaining treatment (WLST) in a large, multicenter stroke registry, and evaluated temporal trends in these associations.
Nina Massad, Lili Zhou, Brian Manolovitz, Negar Asdaghi, Hannah Gardener, Hao Ying, Carolina M. Gutierrez, Angus Jameson, David Rose, Mohan Kottapally, Amedeo Merenda, Kristine O'Phelan, Sebastian Koch, Jose G. Romano, Tatjana Rundek, Ayham Alkhachroum   +15 more
wiley   +1 more source

Factors Affecting Drug-Development Strategies in Asian Global Clinical Trials for Drug Approval in Japan. [PDF]

Clin Transl Sci, 2018
Asano K, Uyama Y, Tohkin M.
europepmc   +1 more source

Progress and Trends for Cancer Drug Approval – an Analysis of FDA Advisory Committee

, 2012
J.K. Chan, Idoroenyi Amanam, T. Kiet, N. Young‐Lin, Daniel F. Hoth, Daniel S. Kapp, B.J. Monk   +6 more
openalex   +1 more source

Digital Activity Markers in Chronic Inflammatory Demyelinating Polyneuropathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the utility of smartwatch and smartphone‐based activity metrics for assessing disease severity and quality of life in patients with chronic inflammatory demyelinating polyneuropathy (CIDP). Methods In the electronic monitoring of disease activity in patients with CIDP (EMDA‐CIDP) trial, we performed a prospective ...
Lars Masanneck, Jan Voth, Noëmi Gmahl, Konstantin Jendretzky, Niklas Huntemann, Noah M. Werner, Linea Schmidt, Menekse Oeztuerk, Paula Quint, Christina B. Schroeter, Hans Peter Hartung, Thomas Skripuletz, Gerd Meyer zu Hörste, Tobias Ruck, Sven G. Meuth, Marc Pawlitzki   +15 more
wiley   +1 more source

Drug approval status and recommendations for listing on public formularies: a Canadian cohort analysis. [PDF]

BMJ Open, 2017
Lexchin J.
europepmc   +1 more source

U.S. Food and Drug Administration Approval: Peginterferon-alfa-2b for the Adjuvant Treatment of Patients with Melanoma

, 2012
Thomas M. Herndon, Suzanne Demko, Xiaoping Jiang, Kun He, Joseph E. Gootenberg, Martin H. Cohen, Patricia Keegan, Richard Pazdur   +7 more
openalex   +1 more source

The Road Not Taken: Misclassifying an Anti‐Seizure Medication as a Failure

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To quantify how often anti‐seizure medications (ASMs) appear ineffective yet provide benefit when considering seizure frequency (SF) variability. Methods We used the CHOCOLATES seizure diary simulator to generate 100,000 patient seizure diaries that reflect natural SF variation in a heterogeneous population.
Christopher N. Henry, Daniel M. Goldenholz   +1 more
wiley   +1 more source

A descriptive research: Exclusion from submitted clinical data package in the review process of new drug approval due to GCP violation in Japan. [PDF]

Contemp Clin Trials Commun, 2019
Asada R, Yoshimura K, Hattori K, Nonaka Y, Kasai H, Shimizu S.   +5 more
europepmc   +1 more source

Comparative Effect of Standard Versus Extended Interval Dosing of Rituximab or Ocrelizumab in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aimed to investigate the comparative effectiveness of standard versus personalized extended interval dosing of anti‐CD20 therapy on clinical and sub‐clinical outcomes in multiple sclerosis. Methods Clinical information was collected prospectively on Research Electronic Data Capture.
Nabil K. El Ayoubi, Fares Fahd, Hani Tamim, Salem Hannoun, Mark Bal, Elham El‐Hallak, Samia J. Khoury   +6 more
wiley   +1 more source

U.S. Food and Drug Administration Approval Summary: Omacetaxine Mepesuccinate as Treatment for Chronic Myeloid Leukemia

, 2013
Firoozeh Alvandi, Virginia E. Kwitkowski, Chia‐Wen Ko, Mark D. Rothmann, Stacey Ricci, Haleh Saber, Debasis Ghosh, Janice Brown, Erika A. Pfeiler, Elsbeth G. Chikhale, Joseph A. Grillo, Julie Bullock, Robert C. Kane, Edvardas Kaminskas, Ann T. Farrell, Richard Pazdur   +15 more
openalex   +1 more source