Results 291 to 300 of about 1,461,601 (371)

Assessing proton plans with three different beam delivery systems versus photon plans for head and neck tumors

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose To compare plan quality among photon volumetric modulated arc therapy (VMAT) and intensity‐modulated proton therapy (IMPT) with robustness using three different proton beam delivery systems with various spot size (σ) ranges: cyclotron‐generated proton beams (CPBs) (σ: 2.7–7.0 mm), linear accelerator proton beams (LPBs) (σ: 2.9–5.5 mm),
Tara Gray, Chieh‐Wen Liu, Saeed Ahmed, Anna Maria Kolano, Jeremy Donaghue, Shlomo Koyfman, Neil Woody, Shauna R. Campbell, Jonathan B. Farr, Ping Xia   +9 more
wiley   +1 more source

Real World Data and Evidence: Support for Drug Approval: Applications to Kidney Diseases.

Clin J Am Soc Nephrol, 2019
Thompson AM, Southworth MR.
europepmc   +1 more source

Fast-track drug approval in inflammatory bowel diseases. [PDF]

Ann Gastroenterol, 2016
Katsanos KH, Koutroumpakis E, Giagkou E, Malakos Z, Almpani E, Skamnelos A, Christodoulou DK.   +6 more
europepmc   +1 more source

U.S. Food and Drug Administration Approval: Peginterferon-alfa-2b for the Adjuvant Treatment of Patients with Melanoma

, 2012
Thomas M. Herndon, Suzanne Demko, Xiaoping Jiang, Kun He, Joseph E. Gootenberg, Martin H. Cohen, Patricia Keegan, Richard Pazdur   +7 more
openalex   +1 more source

Left hippocampus sparing model for glioblastoma radiotherapy by utilizing knowledge‐based planning and multi‐criteria optimization

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose Results of a prospective, randomized controlled trial at our institute demonstrate an association between the dose to the left hippocampus and neurocognitive decline post‐radiotherapy for patients with glioblastoma. To minimize the dose to the left hippocampus, a left hippocampus sparing model was created using RapidPlan (RP) and multi‐
Shima Y. Tari, Amr Heikal, Connie Le, Fan Yang, Deepak Dinakaran, John Amanie, Albert Murtha, Lindsay S. Rowe, Wilson H. Roa, Samir Patel   +9 more
wiley   +1 more source

Physicians' Trust in the FDA's Use of Product-Specific Pathways for Generic Drug Approval. [PDF]

PLoS One, 2016
Kesselheim AS, Eddings W, Raj T, Campbell EG, Franklin JM, Ross KM, Fulchino LA, Avorn J, Gagne JJ.   +8 more
europepmc   +1 more source

Progress and Trends for Cancer Drug Approval – an Analysis of FDA Advisory Committee

, 2012
J.K. Chan, Idoroenyi Amanam, T. Kiet, N. Young‐Lin, Daniel F. Hoth, Daniel S. Kapp, B.J. Monk   +6 more
openalex   +1 more source

IROC phantoms accurately detect MLC delivery errors

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose We evaluated the impact of random and whole‐bank multileaf collimator (MLC) delivery errors on dosimetric delivery accuracy in the Imaging and Radiation Oncology Core (IROC) phantom audits, as well as differences in delivery accuracy between the IROC phantom prescription and typical clinical fraction sizes.
Sharbacha S. Edward, Julianne M. Pollard‐Larkin, Peter A. Balter, Rebecca M. Howell, Christine B. Peterson, Stephen F. Kry   +5 more
wiley   +1 more source

ClinicalTrials.gov and Drugs@FDA: A Comparison of Results Reporting for New Drug Approval Trials. [PDF]

Ann Intern Med, 2016
Schwartz LM, Woloshin S, Zheng E, Tse T, Zarin DA.   +4 more
europepmc   +1 more source

The effect of multi‐leaf collimator leaf width on VMAT treatment plan quality

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Background The advent of volumetric modulated arc therapy (VMAT) in radiotherapy has made it one of the most commonly used techniques in clinical practice. VMAT is the delivery of intensity modulated radiation therapy (IMRT) while the gantry is in motion, and existing literature has shown it has decreased treatment delivery times and the ...
Gregory Sadharanu Peiris, Brendan Whelan, Nicholas Hardcastle, Suzie Lynn Sheehy   +3 more
wiley   +1 more source