Results 41 to 50 of about 322,888 (285)

Nitazenes: The Emergence of a Potent Synthetic Opioid Threat

Molecules
The global unregulated drug supply faces a critical challenge with the emergence of nitazenes, a class of novel synthetic opioids (NSOs) structurally distinct from fentanyl and associated with extreme potency and high risk of fatal overdose.
Joana R. P. Pereira, Alexandre Quintas, Nuno R. Neng   +2 more
doaj   +1 more source

Drug Checking: A prevention measure for a heterogeneous group with high consumption frequency and polydrug use - evaluation of zurich's drug checking services

Harm Reduction Journal, 2011
Background The increasing party culture in Zurich presents new challenges, especially regarding the consumption of alcohol and so-called party drugs. Streetwork, the youth advisory service of the city of Zurich, has provided onsite and stationary Drug ...
Schaub Michael, Buecheli Alexander, Hungerbuehler Ines   +2 more
doaj   +1 more source

'I t’s not going to be a one size fits all': a qualitative exploration of the potential utility of three drug checking service models in Scotland

Harm Reduction Journal, 2023
Background Scotland currently has the highest rates of drug-related deaths in Europe, so drug checking services are being explored due to their potential role in reducing these deaths and related harms.
Hannah Carver, Danilo Falzon, Wendy Masterton, Bruce Wallace, Elizabeth V. Aston, Fiona Measham, Carole Hunter, Harry Sumnall, Rosalind Gittins, Fiona Raeburn, Vicki Craik, Saket Priyadarshi, Laura Rothney, Kira Weir, Tessa Parkes   +14 more
doaj   +1 more source

Advances in Paper Spray Mass Spectrometry (PS-MS) for On-Site Harm Reduction Drug Checking and Illicit Supply Surveillance

AppliedChem
Harm reduction drug checking utilizing paper spray mass spectrometry (PS-MS) has been the focus of ongoing research since 2017 and has seen many refinements. The presented work is the result of this research and has led to the public-facing PS-MS use for
Taelor M. Zarkovic, Lucas R. Abruzzi, Collin Kielty, Bruce Wallace, Dennis K. Hore, Chris G. Gill   +5 more
doaj   +1 more source

Measurement and models accounting for cell death capture hidden variation in compound response. [PDF]

, 2020
Cancer cell sensitivity or resistance is almost universally quantified through a direct or surrogate measure of cell number. However, compound responses can occur through many distinct phenotypic outcomes, including changes in cell growth, apoptosis, and
Bae, Song Yi, Guan, Ning, Meyer, Aaron S, Taylor, Scott D, Warner, Katrina, Yan, Rui   +5 more
core   +1 more source

Proposed best practice for projects that involve modelling and simulation [PDF]

, 2017
Modelling and simulation has been used in many ways when developing new treatments. To be useful and credible, it is generally agreed that modelling and simulation should be undertaken according to some kind of best practice.
Anisimov, Burman, Burton, Cook, European Medicines Agency, Gaydos, Hemmings, Marshall, Smith   +8 more
core   +1 more source

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

Evaluasi Profil Penyimpanan Obat Di Rumah Sakit Islam Faisal Kota Makassar Terhadap Pelayanan Kefarmasian

JUMANTIK (Jurnal Ilmiah Penelitian Kesehatan), 2022
Drug storage is a method of maintaining pharmaceutical supplies aimed at maintaining the quality of a drug. Improper storage of drugs can cause drug damage, be ineffective in treatment, and will be a loss to the hospital. The purpose of this study was to
Nurlina Nurlina, Andi Maulana Kamri, Andi Nadilla Arfah   +2 more
doaj   +1 more source

Navigating Independent Double Checks for Safer Care: A Nursing Perspective [PDF]

, 2015
The purpose of this study was to explore registered nurses’ understanding and practice of “independent double-checks” prior to administration of high-alert medications. The study used a qualitative descriptive design for data collection and data analysis.
Grant, Danielle D
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source