Results 51 to 60 of about 2,161,716 (285)
A Small‐Molecule Drug for the Self‐Checking of Mitophagy
Angewandte Chemie International EditionAbstract Mitophagy, particularly in the context of drugs that disrupt mitochondrial membrane potential (MMP), represents a critical focus in pharmacology. However, the discovery and evaluation of MMP‐disrupting drugs are often hampered using commercially available marker molecules that target similar or identical ...
Yanan Gao +9 more
openaire +3 more sources
Drug checking to detect fentanyl and new psychoactive substances [PDF]
, 2020 Purpose of reviewDrug checking services invite drug consumers to anonymously submit drug samples for chemical analysis and provide feedback of results. Drugs are tested for strength/dose and/or presence of adulterants.
Palamar, JJ +2 more
core +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Drug checking: a potential solution to the opioid overdose epidemic?
Substance Abuse Treatment, Prevention, and Policy, 2018 Background North America is experiencing an overdose epidemic driven in part by the proliferation of illicitly-manufactured fentanyl and related analogues. In response, communities are scaling up novel overdose prevention interventions. Included are drug
Geoff Bardwell, Thomas Kerr
doaj +1 more source
JUMANTIK (Jurnal Ilmiah Penelitian Kesehatan), 2022 Drug storage is a method of maintaining pharmaceutical supplies aimed at maintaining the quality of a drug. Improper storage of drugs can cause drug damage, be ineffective in treatment, and will be a loss to the hospital. The purpose of this study was to
Nurlina Nurlina +2 more
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Symbolic model checking of logics with actions [PDF]
, 2006 Reasoning about agents and modalities such as knowledge and belief leads to models where different relations over states co-exist, or equivalently, where information (labels, actions) is associated to state transitions.
Raimondi, F. +4 more
core
Sample drug checking Fourier-transform infrared spectra.
, 2023 Drug checking samples (blue) are overlaid with the fentanyl hydrochloride spectrum (black). The drug sample in A is an illicit opioid mixture containing fentanyl, caffeine, and mannitol.
Brandon D. L. Marshall (7820615) +5 more
core +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source