Results 71 to 80 of about 2,161,716 (285)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Check Your Chems International. Information, Drug Checking and Sexual Advice.

, 2023
{"references": ["Advisory Council on the Misuse of Drugs. (2010). Consideration of the Cathinones. In Advisory Council on the Misuse of Drugs. https://www.gov.uk/government/publications/acmd-report-on-the-consideration-of-the-cathinones", "Ann Fordham. (2022, December 22). \"Drug-free world\" no more!
Garo, Jordi, Moreno, Laura, Siebers, Sara   +2 more
openaire   +1 more source

Symposium: 2024: the year of multiple drug checking services in Australia

Aim: In 2024, multiple new drug checking initiatives have commenced in Australia, including a community-based service in Brisbane, festival drug checking services in Queensland, drug checking services at Sydney's medically supervised injecting centre ...
Kill, Emma, Barratt, Monica, Puljevic, Cheneal, Davey, Geoff, Piatkowski, Timothy, Page, Robert   +5 more
core   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Xylazine test strip utilization among pregnant and postpartum women with opioid use disorder: A pilot study

Pregnancy
Introduction The emergence of xylazine, a veterinary alpha‐2 and kappa opioid receptor agonist, as an adulterant in illicitly manufactured fentanyl has created new challenges and risks for pregnant people who use unregulated opioids. Xylazine test strips
Ilana Hull, Margaret Shang, Elizabeth Krans, Ellen Stewart, Megan Ritter, Lauren Narbey, Samantha Mayo, Raagini Jawa   +7 more
doaj   +1 more source

Current attitudes toward drug checking services and a comparison of expected with actual drugs present in street drug samples collected from opioid users

Harm Reduction Journal, 2023
Background The opioid epidemic continues to be associated with high numbers of fatalities in the USA and other countries, driven mainly by the inclusion of potent synthetic opioids in street drugs.
James A. Swartz, Marya Lieberman, A. David Jimenez, Mary Ellen Mackesy-Amiti, Heather D. Whitehead, Kathleen L. Hayes, Lisa Taylor, Elizabeth Prete   +7 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Recommendations from people who use drugs in Philadelphia, PA about structuring point-of-care drug checking

Harm Reduction Journal
Background Adulterants, such as fentanyl and xylazine, among others, are present in a high percentage of the illicit drug supply, increasing the risk for overdose and other adverse health events among people who use drugs (PWUD).
Megan K. Reed, Elias Borne, Tracy Esteves Camacho, Morgan Kelly, Kristin L. Rising   +4 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

The Effect of External Influences on Drug Trends at Music Festivals in New Zealand, 2018 to 2023

Emerging Trends in Drugs, Addictions, and Health
Introduction: Changes in the drug trends seen at music festivals in New Zealand may be influenced by factors, such as the availability of the drugs, enforcement activities, media attention and legislative changes to drug checking services.
L. Philip, C. Black, G. Powell, L. Clark, C. Johnson, O. Johnson   +5 more
doaj   +1 more source