Results 81 to 90 of about 2,161,716 (285)
, 2020 INTRODUCTION: Drug sellers are often represented as morally bereft actors and as being, in part, responsible for North America's overdose crisis. In Canada and the United States, drug sellers selling fentanyl and fentanyl-adulterated drugs have been ...
Kerr, Thomas +5 more
core +1 more source
Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins
FEBS Open Bio, EarlyView.Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley +1 more source
Drug-drug interaction checking assisted by clinical decision support:a return on investment analysis [PDF]
, 2015 Background Drug-drug interactions (DDIs) are very prevalent in hospitalized patients. Objectives To determine the number of DDI alerts, time saved, and time invested after suppressing clinically irrelevant alerts and adding clinical-decision support to ...
Kosterink, Jos G. W.; id_orcid +4 more
core +1 more source
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
Drugs arriving in Kosovo need checking
BMJ, 1999 EDITOR—3As deputy head and consultants of the health department of EUAM (European Union Administration of Mostar) in 1995-6 we were impressed by Saunders's article concerning drug donations.1 In Bosnia these problems appeared for a variety of complex reasons that have been widely recognised.2–4 The problem of private donations in former Yugoslavia was ...
G. L. Quaglio, P. Mezzelani, C. Cuchillo
openaire +2 more sources
Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
Fl Drug Checking Empowering Communities
Drug Checking is a tool for empowering ...
Massey, Illyana
core +1 more source
The Evaluation of a Drug Checking Software Platform that Enables Remote Point-of-Care Drug Checking
, 2023 In April 2016, drug-related overdoses were declared a public health emergency in British Columbia, Canada. At the heart of this public health emergency is fentanyl, a synthetic opioid and the most commonly detected drug in illicit drug toxicity deaths.
Robinson, Derek
core
Protocol for quantifying miRNA trafficking across the endosomal membrane
FEBS Open Bio, EarlyView.An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source
Harm Reduction JournalBackground Shifts in the US drug supply, including the proliferation of synthetic opioids and emergence of xylazine, have contributed to the worsening toll of the overdose epidemic.
Kyle J. Moon +9 more
doaj +1 more source