Results 91 to 100 of about 6,210,399 (255)

Safe beats down under: investigating the support of drug checking at a regional festival in the Northern Territory, Australia

Background In the context of Australian music festivals, including those in the Northern Territory (NT), drug-related harms persist. This study focused on gathering local insights into drug-related behaviours and attitudes, particularly regarding drug ...
Clifford, Sarah, Dietze, Paul, Wright, Cassandra, Lim, Megan, Douglass, Caitlin, Brett, Jonathan, Moore, Samuel, Miller, Mia, Piatkowski, Timothy, Wardle, Felicity, Hill, Penny, Peacock, Amy, Brett, J ; https://orcid.org/, Wardle, F, Lim, M, Piatkowski, T, Wright, CJC, Miller, M ; https://orcid.org/, Hill, P ; https://orcid.org/, Moore, S, Dietze, P ; https://orcid.org/, Peacock, A ; https://orcid.org/, Douglass, C, Clifford, S ; https://orcid.org/   +23 more
core   +1 more source

Smartphone‐Guided Visible Light Modulation of RSNOs for Antimicrobial Activity via Controlled Nitric Oxide Release

Advanced Science, EarlyView.
A light‐activated catheter insert combines antimicrobial blue light with nitric oxide release to generate complementary oxidative and nitrosative stress, producing potent broad‐spectrum antimicrobial activity. The approach achieves greater than 4‐log reductions in bacterial and fungal viability and significantly reduces Staphylococcus aureus ...
Alexander Bruckmann, Adam Brooks Goodman, Myddelton C. Parker, Mark Garren, Ji Eun Park, Chad Schmiedt, Hitesh Handa, Elizabeth J. Brisbois   +7 more
wiley   +1 more source

On‐site identification of psychoactive drugs by portable Raman spectroscopy during drug‐checking service in electronic music events

Drug and Alcohol Review, 2019
AbstractIntroduction and AimsHundreds of new psychoactive substances (NPS) have burst into the marketplace, making both the scientific community and people who use drugs lacking of adequate information about their diffusion and effects. In this scenario, drug‐checking services have been recently proposed to assist harm reduction policies and provide a ...
Gerace E., Seganti F., Luciano C., Lombardo T., Di Corcia D., Teifel H., Vincenti M., Salomone A.   +7 more
openaire   +3 more sources

Take-home drug checking as a novel harm reduction strategy in British Columbia, Canada.

, 2022
BACKGROUND: Drug checking is a harm reduction strategy used to identify components of illicitly obtained drugs, including adulterants, to prevent overdose.
Lysyshyn, Mark, Klaire, Sukhpreet, Buxton, Jane A, Janssen, Renée M, Korol, Ellen E, Olson, Karmen, Bridgeman, Jessica, Sabeti, Soha, Chu, Tim, Ghafari, Cher   +9 more
core   +1 more source

Tracking CDK1 Dynamics With a Novel Biosensor Mouse and Clinical Cohorts to Predict CDK4/6 Inhibitor Sensitivity in ER+ Breast Cancer

Advanced Science, EarlyView.
Cyclin‐dependent kinase (CDK) 1 activity is a dynamic marker of treatment response in estrogen receptor positive breast cancer. Patient cohorts reveal CDK1 activity increases during progression to invasive disease, where high expression correlates with poor survival. Using a novel Cdk1 biosensor mouse alongside in vitro models, we demonstrate that CDK1
Sarah Alexandrou, Kristine J. Fernandez, Min Li Huang, Ewan K. A. Millar, Claire Vennin, Leila Eshraghi, Tan Dat Timothy Lam, Victoria Lee, Nyah C. Brooks, Janett Stoehr, Cristian Guaman Mendez, Douglas Strathdee, David Stevenson, David Herrmann, Sandra O'Toole, Paul Timpson, Max Nobis, C. Elizabeth Caldon   +17 more
wiley   +1 more source

The magistrates' handbook of diversionary programs and services for alcohol and drug related offending / Alcohol and other drug services, Territory Health Services

, 2000
This information handbook is a reference to the agencies that provide assessment and treatment programs for people whose offending I behaviour is linked with drug and alcohol use (1999 - 2000 edition)
Alcohol and Other Drug Services
core  

Real‐Time Monitoring of Mass and Mechanical Properties in Single Cells and Multicellular Spheroids

Advanced Science, EarlyView.
This study introduces photothermally actuated microcantilevers combined with optical microscopy to simultaneously measure morphology, mass, and mechanical properties of cellular systems in real‐time. The findings link cytoplasm‐dominated mechanical energy dissipation to the Q‐factor as a novel biophysical parameter.
Ilaria Incaviglia, Giulia E. M. Ammirati, Sophie Herzog, Tommy Krug, Nico Strohmeyer, Miguel Camacho Rufino, Matthias P. Lutolf, David A. Weitz, Daniel J. Müller   +8 more
wiley   +1 more source

The Evaluation of a Drug Checking Software Platform that Enables Remote Point-of-Care Drug Checking

, 2023
In April 2016, drug-related overdoses were declared a public health emergency in British Columbia, Canada. At the heart of this public health emergency is fentanyl, a synthetic opioid and the most commonly detected drug in illicit drug toxicity deaths.
Robinson, Derek
core  

Mechanism‐Informed Language Modeling and Oxygenated 3D Screening Identify Berberine–Enzalutamide Synergy in Prostate Cancer Models

Advanced Science, EarlyView.
By integrating knowledge‐augmented artificial intelligence with an oxygen‐supplemented 3D screening platform, a synergistic interaction between berberine and enzalutamide is identified. The framework integrates compound mechanisms of action with disease‐relevant signaling context to prioritize candidate combinations and generate testable pathway‐based ...
Chih‐Hui Lo, Katie Shi, Lina Kafadarian, Alexandra Bermudez, Johnny Diaz, Liam Edwards, Yunqi Hong, Ziyi Chen, Hyeonji Hwang, Weihong Yan, Alan Levinson, Robert Damoiseaux, Cho‐Jui Hsieh, Tanya Stoyanova, Andrew S. Goldstein, Neil Y.C. Lin   +15 more
wiley   +1 more source

Implementation opportunities and challenges to piloting a community-based drug-checking intervention for sexual and gender minority men in Vancouver, Canada: a qualitative study

Harm Reduction Journal
Background In response to the overdose crisis, a collaborative group of two community-based organizations, a health authority and a research institute in Vancouver, Canada, implemented a pilot community-based drug checking (CBDC) intervention for sexual ...
Pierre-julien Coulaud, Koharu Loulou Chayama, Cameron Schwartz, Aaron Purdie, Mark Lysyshyn, Lianping Ti, Rod Knight   +6 more
doaj   +1 more source