Results 101 to 110 of about 6,210,399 (255)

Melatonin Mitigates Doxorubicin‐Induced Cardiotoxicity by Targeting the USP18/PKM2 Axis Without Compromising Antitumor Efficacy

Advanced Science, EarlyView.
Melatonin engages MT1/MT2 receptors to suppress STAT1‐driven USP18 upregulation, thereby redirecting PKM2 ubiquitination from K33‐linked autophagic degradation toward K27‐linked nuclear translocation. This prevents PKM2‐mediated proinflammatory gene expression in the heart, alleviating doxorubicin‐induced cardiotoxicity without compromising antitumor ...
Zhenyu Feng, Yijin Yang, Jie Bai, Pengqi Sun, Xuyang Sun, Jinshu Shang, Yang Liu, Zhen Ning, Ningning Zhang, Yun‐long Xia, Yunpeng Xie   +10 more
wiley   +1 more source

From trash to results: shortcomings and benefits of paraphernalia-based drug checking in Finland

Harm Reduction Journal
Background Drug checking is a harm reduction intervention that combines the identification of the chemical content of a drug with an information-sharing intervention concerning the risks of drug use.
Teemu Kaskela, Janne Nahkuri, Aino Kankaanpää, Anna Pelander, Teemu Gunnar, J. Tuomas Harviainen, Jouni Tourunen   +6 more
doaj   +1 more source

The Interplay Between Molybdopterin Synthase and Metal Metabolism Contributes to Pathogenicity in Acinetobacter baumannii

Advanced Science, EarlyView.
Pathogenic Acinetobacter baumannii scavenges metal ions as nutritional elements to survive within the host. This study demonstrates that molybdopterin synthase is essential for pathogenesis and full virulence during infection. Molybdopterin synthase subunit MoaE constitutes an intrinsically disordered C‐terminal histidine rich tail, which mediates ...
Min Jiao, Wenbo He, Zhenlin Ouyang, Ruochen Wang, Jiaxin Zhang, Xin Liu, Yiting Jing, Qinyue Yu, Xiaoyu He, Qian Qin, Litao Guo, Peter M. Hwang, Fang Zheng, Yurong Wen   +13 more
wiley   +1 more source

Impact measurement tool for drug and alcohol services 2020/21.

, 2022
The impact measurement tool (IMT) is a data collection system used to assess the effectiveness of tier one and tier two drug & alcohol services commissioned by the Public Health Agency (PHA)

core  

A Single‐Capillary Open Microfluidic Probe for Robust and Versatile Spatial Multi‐Omics Using Ambient Mass Spectrometry Imaging

Advanced Science, EarlyView.
This study reports a knot‐shaped single‐capillary open microfluidic probe (Knot‐probe) for robust and versatile spatial omics, enabling ambient mass spectrometry imaging with high spatial resolution, throughput, and structure‐resolved capability. Knot‐probe mitigates the trade‐off between analytical performance and operational robustness, providing an ...
Xiangyu Zhu, Yunkai Li, Jianing Wang, Chengyi Xie, Lei Guo, Yanyan Chen, Thomas Ka‐Yam Lam, Shao‐Wen Shi, Kun Wang, Baoliang Chen, Zongwei Cai   +10 more
wiley   +1 more source

Agronomic and Nutritional Perspectives on Vegetable Crops in Africa

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Vegetable production plays a key role in food security, nutrition, and livelihoods across Africa. Moreover, African indigenous vegetables emerge as underutilized yet highly valuable crops, rich in macro‐ and micronutrients, as well as bioactive compounds with an array of health benefits.
Đorđe Vojnović, Pamela Owusu Osei, Sina Siavash Moghaddam, Issiake Konate, Jelena Popović‐Đorđević   +4 more
wiley   +1 more source

Factors associated with obtaining prescribed safer supply among people accessing harm reduction services: findings from a cross-sectional survey

Harm Reduction Journal
Background With growing rates of unregulated drug toxicity death and concerns regarding COVID-19 transmission among people who use drugs, in March 2020, prescribed safer supply guidance was released in British Columbia.
Heather Palis, Beth Haywood, Jenny McDougall, Chloé G. Xavier, Roshni Desai, Samuel Tobias, Heather Burgess, Max Ferguson, Lisa Liu, Brooke Kinniburgh, Amanda K. Slaunwhite, Alexis Crabtree, Jane A. Buxton   +12 more
doaj   +1 more source

Prevalence of fentanyl in methamphetamine and cocaine samples collected by community-based drug checking services. [PDF]

Drug Alcohol Depend, 2023
Wagner KD, Fiuty P, Page K, Tracy EC, Nocera M, Miller CW, Tarhuni LJ, Dasgupta N.   +7 more
europepmc   +1 more source

Pricing Dynamics in the US Hemp Market: A Vertical Price Transmission Analysis of the Hemp Value Chain

Agribusiness, EarlyView.
ABSTRACT The US hemp market is a new and nascent industry that has been devoid of research for about half a century. This study examined the effects of exogenous shock on price at each phase of the value chain—Farm (hemp biomass), and its impact on prices at other phases of the value chain—Intermediary Processor (crude cannabidiol hemp) and Final ...
Solomon Odiase, Tyler Mark, Patalee Buddhika Appuhamilage   +2 more
wiley   +1 more source

Harm reduction behaviours and harm experiences of people who use 3,4-methylenedioxymethamphetamine (MDMA) in Aotearoa New Zealand

Harm Reduction Journal
Background 3,4-Methylenedioxymethamphetamine (MDMA) is drug of high prevalence in Aotearoa New Zealand and is the primary drug analysed by legal drug checking services.
Jai Whelan, Geoff Noller, Ryan D. Ward
doaj   +1 more source