Results 81 to 90 of about 5,698,960 (306)

Lorlatinib‐Containing Therapy for MYCN‐Amplified, ALK‐Mutated Neuroblastoma With Bulky Leptomeningeal Relapse: A Case Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Central nervous system (CNS) relapse of neuroblastoma carries a poor prognosis, and craniospinal irradiation (CSI) poses substantial long‐term toxicity in young children. We report a toddler with MYCN‐amplified neuroblastoma harboring somatic ALK R1275Q who developed extensive leptomeningeal relapse with paraplegia.
Jinwoo Kim, Minji Kim, Nani Jung, Sung Eun Kim, Ji Yoon Kim, Mi Ae Chu, Jung Eun Kwon, Yeo Hyang Kim, So Mi Lee, Ki‐Su Park, Jeong Eun Lee, Ye Jee Shim   +11 more
wiley   +1 more source

In Vitro Assessment of the Combined Activity of Amphotericin B and Cu²⁺-1,10-Phenanthroline-5,6-dione Coordination Compound Against Leishmania amazonensis Promastigotes

Tropical Medicine and Infectious Disease
Leishmaniasis is a severe parasitic disease transmitted by sandflies that affects both humans and animals, with clinical manifestations ranging from cutaneous lesions to life-threatening visceral involvement.
Simone Santiago Carvalho de Oliveira, Débora Duarte Batista, Michael Devereux, Malachy McCann, Christiane Fernandes, André Luis Souza dos Santos, Marta Helena Branquinha   +6 more
doaj   +1 more source

Experience With Performing Rheocarna Therapy via the Single‐Needle Method for Treatment of Chronic Limb‐Threatening Ischemia

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This study investigated the safety and efficacy of single‐needle Rheocarna therapy for chronic limb‐threatening ischemia (CLTI) with wounds. Methods Six patients with CLTI involving ulcers unresponsive to revascularization underwent single‐needle Rheocarna treatment.
Yasutaka Yamauchi, Rie Tanaka, Reona Kawahira, Shingo Nabeta, Kouhei Naoi, Kazuhito Kitajima, Akira Wada, Tomonari Takagi, Norihiko Ohura, Akira Miyamoto   +9 more
wiley   +1 more source

Effect of Combination Therapy on Drug Efficacy.

, 2014
Max  =  maximum efficacy, the drug or drug combination that achieved the maximum efficacy is indicated in bold, BPM  =  beats per minute.Effect of Combination Therapy on Drug Efficacy.
Laura S. Stone (286609), Jonathan P. German (642087), Carolyn A. Fairbanks (485520), Kelly F. Kitto (642088), George L. Wilcox (485519)   +4 more
core   +1 more source

Combination of drug selection, and dose indexes.

, 2022
Combination of drug selection, and dose indexes.
Reyhane Izadi (12883973), Nader Jahanmehr (8673921), Abbas Habibolahi (12883976), Soheila Khodakarim (8293494), Setareh Yousefzadeh (12883979)   +4 more
core   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology
Triple‐negative breast cancer (TNBC) remains the breast cancer subtype with the poorest prognosis. While PARP inhibitors (PARPi) effectively target BRCA1/2‐mutant TNBCs via synthetic lethality, most TNBCs are BRCA1/2 wild‐type.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
doaj   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Drug combination to treat SARS-CoV-2.

, 2023
Drug combination to treat SARS-CoV-2.
Mei Ma (2271595), Xiujuan Lei (5374532)
core   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Cost-effectiveness study of three antimalarial drug combinations in Tanzania. [PDF]

, 2006
BACKGROUND: As a result of rising levels of drug resistance to conventional monotherapy, the World Health Organization (WHO) and other international organisations have recommended that malaria endemic countries move to combination therapy, ideally with ...
Theonest K Mutabingwa, Whitty, CJM, Michelle Kim, Virginia Wiseman, Mutabingwa, TK, Mutabingwa Theonest K, Kim, Michelle, Wiseman Virginia, Wiseman, Virginia, Christopher J M Whitty, Wiseman, V ; https://orcid.org/, Mutabingwa, Theonest K, Whitty Christopher J. M, Whitty, Christopher JM, Kim Michelle, Kim, M   +15 more
core   +1 more source