Results 91 to 100 of about 793,336 (333)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Compensatory effects in the PI3K/PTEN/AKT signaling network following receptor tyrosine kinase inhibition [PDF]

, 2011
Overcoming de novo and acquired resistance to anticancer drugs that target signaling networks is a formidable challenge for drug design and effective cancer therapy.
Bown, James L., Faratian, Dana, Goltsov, Alexey, Goryanin, Igor, Harrison, David J., Langdon, Simon P.   +5 more
core   +4 more sources

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Enhanced killing of antibiotic-resistant bacteria enabled by massively parallel combinatorial genetics [PDF]

, 2014
New therapeutic strategies are needed to treat infections caused by drug-resistant bacteria, which constitute a major growing threat to human health.
Cheng, Allen A., Ding, Huiming, Lu, Timothy K.   +2 more
core   +1 more source

In vitro Synergistic Activity of Colistin-Based Antimicrobial Combinations against Extensively Drug-Resistant (XDR) Acinetobacter baumannii from a Tertiary Hospital in Greece [PDF]

, 2022
Paraskevi Mantzana, Efthymia Protonotariou, Angeliki Kassomenaki, Maria Arhonti, Georgios Meletis, Olga Vasilaki, Georgia Kagkalou, Lemonia Skoura   +7 more
openalex   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Assessment of knowledge, attitude and practice of fixed-dose combinations amongst attending physicians and residents: a cross-sectional evaluation

Drugs in Context
Background: Fixed-dose combinations (FDCs) were brought into the market with the intent of providing benefits primarily to patients and physicians.
Dhyuti Gupta, Prithpal Singh Matreja, Shilpa Patrick, Meenu Thomas, Pooja Agarwal, Preeti Singh   +5 more
doaj   +1 more source

Research Progress of Epigenetics in Pathogenesis and Treatment of Malignant Tumors

Chinese Journal of Lung Cancer, 2020
Epigenetic modification is closely related to the occurrence and development of tumors. It mainly regulates gene function and expression level through DNA methylation, histone modification, regulation of non-coding RNA and chromatin structure ...
Pan WANG, Honglin ZHAO, Fan REN, Qingchun ZHAO, Ruifeng SHI, Xingyu LIU, Jinghao LIU, Yongwen LI, Ying LI, Hongyu LIU, Jun CHEN   +10 more
doaj   +1 more source

Characterizing genomic alterations in cancer by complementary functional associations. [PDF]

, 2016
Systematic efforts to sequence the cancer genome have identified large numbers of mutations and copy number alterations in human cancers. However, elucidating the functional consequences of these variants, and their interactions to drive or maintain ...
A Azzalini, A Kraskov, A Kraskov, A Singh, A Young, AA Margolin, AJ Butte, Amir Reza Alizad-Rahvar, Andrew Aguirre, Arthur Liberzon, Aviad Tsherniak, B Luo, Barbara A Weir, C Ding, C Scholl, CA Miller, CD Correa, Chet Birger, Chiara Romualdi, CJ Vaske, Cory M Johannessen, D Feng, D Guardavaccaro, D Malhotra, D Nijhawan, D Pandey, DA Barbie, Daniel DiCara, David A Barbie, David J Konieczkowski, DD Shao, Diane D Shao, DP Hollern, DP Minde, DV Foster, EH Linfoot, Eliezer M Van Allen, F Vandin, F Vandin, Francisca Vazquez, G Ciriello, GA Darbellay, Gabriela Alexe, Gabriele Sales, Gad Getz, GM DeNicola, H Joe, H Peng, H Zou, Heidi Greulich, HW Cheung, J Barretina, J Lin, J Rosenbluh, JA McCubrey, Jesse S Boehm, Jill P Mesirov, JN Weinstein, Jong Wook Kim, Joseph Rosenbluh, JP Brunet, JS Boehm, L Chin, L Chin, L Waldron, Levi A Garraway, LM Solis, M Meyerson, Mahmoud Ghandi, Masoud Ardakani, MB Raeder, MD Leiserson, ME Abazeed, Michael Noble, Mohamed E Abazeed, MS Lawrence, MS Lawrence, Olga B Botvinnik, Omar Abudayyeh, P Tamayo, Pablo Tamayo, Peter S Hammerman, R Beroukhim, R Firestein, R Steuer, Rameen Beroukhim, S Pendyala, S Sheather, SS Brar, T Valenta, Travis I Zack, William C Hahn, Y Gu, Yashaswi Shrestha   +93 more
core   +1 more source

Selective Inhibitors of Autophagy Reveal New Link between the Cell Cycle and Autophagy and Lead to Discovery of Novel Synergistic Drug Combinations

, 2022
Kisa Sung, Agata Kurowski, Carisse Lansiquot, Kanny K. Wan, Samarjit Patnaik, Martin J. Walsh, Michael B. Lazarus   +6 more
openalex   +2 more sources