Results 141 to 150 of about 943,135 (348)
Antihypertensive drug combinations [PDF]
Journal of the Korean Medical Association, 2014 고혈압은 다양한 병인을 가진 질환이다. 젊어서는 교감 신경계 또는 레닌-안지오텐신계 활성이 고혈압 발생의 주 기전이고, 그리고 나이가 들어서는 소금 및 볼륨증가가 혈 압상승을 이끄는 주 기전이다. 60여 년 전부터 고혈압 약 제의 개발도 이런 기전에 따라서 베타차단제, 알파차단제, 알파-베타차단제와 같은 교감신경억제제, 체내 소금 및 볼륨을 줄이기 위해 이뇨제와 칼슘채널차단제가 개발되 었고, 안지오텐신수용체차단제 또는 안지오텐신전환효소 억제제와 같은 레닌-안지오텐신계 활성억제제가 개발되 어 성공적으로 사용하고 있고, 최근에는 직접 레닌억제제, 알도스테론 길항제 등이 고혈압 약물로 소개되었다. 최근 에는 우리나라를 비롯하여 여러
openaire +2 more sources
Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance
Molecular Oncology, EarlyView.Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren +4 more
wiley +1 more source
Differential Spectrometric Determination of Caffeine in Soluble Coffee and in Drug Combinations [PDF]
, 1968 William P. Ferren, Norman Shane
openalex +1 more source
Molecular Oncology, EarlyView.CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Chunmei Fan +6 more
wiley +1 more source
mBio, 2019 The rapid spread of multidrug-resistant strains has created a pressing need for new drug regimens to treat tuberculosis (TB), which kills 1.8 million people each year.
Shuyi Ma +6 more
doaj +1 more source
Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value
Molecular Oncology, EarlyView.The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song +13 more
wiley +1 more source
Molecular Oncology, EarlyView.TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam +9 more
wiley +1 more source
International Journal of Nanomedicine, 2014 Anna K Blakney, Emily A Krogstad, Yonghou H Jiang, Kim A WoodrowDepartment of Bioengineering, University of Washington, Seattle, Washington, USABackground: Electrospun drug-eluting fabrics have enormous potential for the delivery of physicochemically ...
Blakney AK +3 more
doaj
Dynamical model-based experiment design for drug repositioning [PDF]
arXivComputational methods in drug repositioning can help to conserve resources. In particular, methods based on biological networks are showing promise. Considering only the network topology and knowledge on drug target genes is not sufficient for quantitative predictions or predictions involving drug combinations.
arxiv