Results 41 to 50 of about 793,626 (282)

Corrigendum: Network-based prediction of anti-cancer drug combinations [PDF]

Frontiers in Pharmacology
Jue Jiang, Xuxu Wei, YuKang Lu, Simin Li, Xue Xu   +4 more
doaj   +2 more sources

Drug Combinations: Mathematical Modeling and Networking Methods

Pharmaceutics, 2019
Treatments consisting of mixtures of pharmacological agents have been shown to have superior effects to treatments involving single compounds. Given the vast amount of possible combinations involving multiple drugs and the restrictions in time and ...
Vahideh Vakil, Wade Trappe
doaj   +1 more source

The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers. [PDF]

, 2011
Encapsulation of drugs within nanocarriers that selectively target malignant cells promises to mitigate side effects of conventional chemotherapy and to enable delivery of the unique drug combinations needed for personalized medicine.
Ashley, Carlee E, Brinker, C Jeffrey, Brown, Page A, Carnes, Eric C, Carroll, Nick J, Carter, Mark B, Chackerian, Bryce, Dunphy, Darren R, Durfee, Paul N, Evans, Deborah G, Hanna, Tracey N, Jiang, Xingmao, Liu, Juewen, Padilla, David, Parikh, Atul N, Peabody, David S, Petsev, Dimiter N, Phillips, Brandy, Phillips, Genevieve K, Wharton, Walker, Willman, Cheryl L   +20 more
core   +2 more sources

Inhibitory Mechanisms of DHA/CQ on pH and Iron Homeostasis of Erythrocytic Stage Growth of Plasmodium falciparum

Molecules, 2019
Malaria is an infectious disease caused by Plasmodium group. The mechanisms of antimalarial drugs DHA/CQ are still unclear today. The inhibitory effects (IC50) of single treatments with DHA/CQ or V-ATPase inhibitor Baf-A1 or combination treatments by DHA/
Tian Tang, Wenhui Xu, Ji Ma, Huajing Wang, Zhao Cui, Tingliang Jiang, Canghai Li   +6 more
doaj   +1 more source

Self-assembly of multi-component fluorescent molecular logic gates in micelles [PDF]

, 2016
A recent strategy for developing supramolecular logic gates in water is based on combinations of molecules via self-assembly with surfactants, which eliminates the need for time-consuming synthesis. The self-assembly of surfactants and lumophores and
Costa, Paola F. da, Magri, David C., Paterson, Kyle A.   +2 more
core   +1 more source

In Vitro Activities of Nisin and Nisin Derivatives Alone and In Combination with Antibiotics against Staphylococcus Biofilms [PDF]

, 2016
peer-reviewedThe development and spread of pathogenic bacteria that are resistant to the existing catalog of antibiotics is a major public health threat.
Cotter, Paul D., Field, Des, Hill, Colin, O'Connor, Rory, Ross, R Paul   +4 more
core   +1 more source

Why and When Are Evidence‐Based Interventions Adopted in Paediatric Supportive Care? A Qualitative Exploration of the Determinants of Photobiomodulation Implementation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Oral mucositis is a common and debilitating side effect of childhood cancer and stem cell transplant treatments. It affects the quality of life of children and young people (CYP) and places a strain on services. Photobiomodulation is recommended for oral mucositis prevention in international guidance but is poorly implemented in UK ...
Claudia Heggie, Kara A. Gray‐Burrows, Peter F. Day, Bob Phillips, Carl A. Thompson   +4 more
wiley   +1 more source

SynergyFinder : a web application for analyzing drug combination dose-response matrix data [PDF]

, 2017
Rational design of drug combinations has become a promising strategy to tackle the drug sensitivity and resistance problem in cancer treatment. To systematically evaluate the preclinical significance of pairwise drug combinations, functional screening ...
Al-Lazikani, Aleksandr Ianevski, Berenbaum, Bliss, Di Veroli, Jing Tang, Knight, Liye He, Loewe, Mathews Griner, Mott, Oliver Stegle, Tang, Tero Aittokallio, Yadav   +14 more
core   +1 more source

Real‐World Pediatric Blinatumomab Administration: Access to Outpatient Care Delivery and Impact of a Hospital‐Dispensed Model

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Blinatumomab has been shown to be highly effective for patients with pediatric B‐ALL and has recently become standard of care therapy. Due to its past use in the clinical trial setting, there is limited information available about real‐world administration.
Katelyn Oranges, Kelly A. Duffy, Sara McDonough, Evelyn Kurpiewski, R. Jennifer Randall, Allison Barz Leahy, Haley M. Newman, Joyce P. Lee, Stephen P. Hunger, Anne F. Reilly, David T. Teachey, Susan R. Rheingold, Daniel J. Zheng   +12 more
wiley   +1 more source

PINet 1.0: A pathway network-based evaluation of drug combinations for the management of specific diseases

Frontiers in Molecular Biosciences, 2022
Drug combinations can increase the therapeutic effect by reducing the level of toxicity and the occurrence of drug resistance. Therefore, several drug combinations are often used in the management of complex diseases.
Yongkai Hong, Dantian Chen, Yaqing Jin, Mian Zu, Yin Zhang   +4 more
doaj   +1 more source