Results 21 to 30 of about 2,669,018 (297)
Review of Predicting Synergistic Drug Combinations
Life, 2023 The prediction of drug combinations is of great clinical significance. In many diseases, such as high blood pressure, diabetes, and stomach ulcers, the simultaneous use of two or more drugs has shown clear efficacy. It has greatly reduced the progression
Yichen Pan +4 more
doaj +1 more source
Broad-Spectrum Antivirals and Antiviral Drug Combinations
Viruses, 2022 Viral diseases consistently pose a substantial economic and public health burden worldwide [...]
Valentyn Oksenych, Denis E. Kainov
doaj +1 more source
Antifungal Combinations in Dermatophytes
Journal of Fungi, 2021 Dermatophytes are the most common cause of fungal infections worldwide, affecting millions of people annually. The emergence of resistance among dermatophytes along with the availability of antifungal susceptibility procedures suitable for testing ...
Lucia Brescini +3 more
doaj +1 more source
Potential Drug Dose-Specific Adverse Three-Drug Combinations: A US Insurance Claims Data-Based Study. [PDF]
Pharmacoepidemiol Drug SafIntroduction: Use of three-drug combinations is increasingly prevalent and associated with an increased risk of adverse drug events (ADEs). While real-world data-based pharmacovigilance and pharmacoepidemiology studies have derived knowledge on potential
Shi Y +12 more
europepmc +2 more sources
Pharmaceutics, 2022 The fast evolution of anti-tumor agents embodies a deeper understanding of cancer pathogenesis. To date, chemotherapy, targeted therapy, and immunotherapy are three pillars of the paradigm for cancer treatment. The success of immune checkpoint inhibitors
Tiancheng Zhang +3 more
doaj +1 more source
AI-driven discovery of synergistic drug combinations against pancreatic cancer. [PDF]
Nat CommunTreatment regimens, especially in cancer, often include more than one medicine in order to achieve durable outcomes. Identifying the optimal combination of treatments has historically been done through clinical trial and error.
Pourmousa M +18 more
europepmc +4 more sources
Molecules, 2021 Despite Alzheimer’s disease (AD) incidence being projected to increase worldwide, the drugs currently on the market can only mitigate symptoms. Considering the failures of the classical paradigm “one target-one drug-one disease” in delivering effective ...
Claudia Albertini +7 more
doaj +1 more source
Viribus Unitis: Drug Combinations as a Treatment Against COVID-19 [PDF]
, 2020 The opportunities that may be provided by synergistic antiviral action of drugs for battling SARS-CoV2 are currently underestimated. Modern AI technologies realized as text, data, and knowledge mining and analytics tools provide the researchers with ...
Alexey, Zakharov, Eugene, Muratov
core +1 more source
New In Vitro-In Silico Approach for the Prediction of In Vivo Performance of Drug Combinations [PDF]
, 2021 Pharmacokinetic (PK) studies improve the design of dosing regimens in preclinical and clinical settings. In complex diseases like cancer, single-agent approaches are often insufficient for an effective treatment, and drug combination therapies can be ...
Cristiana Correia +13 more
core +1 more source
Candyflipping and Other Combinations: Identifying Drug–Drug Combinations from an Online Forum
Frontiers in Psychiatry, 2018 Novel psychoactive substances (NPS) refer to synthetic compounds or derivatives of more widely known substances of abuse that have emerged over the last two decades.
Michael Chary, David Yi, Alex F. Manini
doaj +1 more source