Results 21 to 30 of about 2,834,658 (290)

Candyflipping and Other Combinations: Identifying Drug–Drug Combinations from an Online Forum

Frontiers in Psychiatry, 2018
Novel psychoactive substances (NPS) refer to synthetic compounds or derivatives of more widely known substances of abuse that have emerged over the last two decades.
Michael Chary, David Yi, Alex F. Manini
doaj   +1 more source

AI-driven discovery of synergistic drug combinations against pancreatic cancer. [PDF]

Nat Commun
Treatment regimens, especially in cancer, often include more than one medicine in order to achieve durable outcomes. Identifying the optimal combination of treatments has historically been done through clinical trial and error.
Pourmousa M, Jain S, Barnaeva E, Jin W, Hochuli J, Itkin Z, Maxfield T, Melo-Filho C, Thieme A, Wilson K, Klumpp-Thomas C, Michael S, Southall N, Jaakkola T, Muratov EN, Barzilay R, Tropsha A, Ferrer M, Zakharov AV.   +18 more
europepmc   +4 more sources

Viribus Unitis: Drug Combinations as a Treatment Against COVID-19 [PDF]

, 2020
The opportunities that may be provided by synergistic antiviral action of drugs for battling SARS-CoV2 are currently underestimated. Modern AI technologies realized as text, data, and knowledge mining and analytics tools provide the researchers with ...
Alexey, Zakharov, Eugene, Muratov
core   +1 more source

Understanding the Clinical Use of Levosimendan and Perspectives on its Future in Oncology

Biomolecules, 2023
Drug repurposing, also known as repositioning or reprofiling, has emerged as a promising strategy to accelerate drug discovery and development. This approach involves identifying new medical indications for existing approved drugs, harnessing the ...
Eduarda Ribeiro, Nuno Vale
doaj   +1 more source

Customizing the therapeutic response of signaling networks to promote antitumor responses by drug combinations [PDF]

, 2014
This work was supported by grants from Breakthrough Breast Cancer and Scottish Funding Council (SRDG), and personal support to Alexey Goltsov from Scottish Informatics and Computer Science Alliance (SICSA) and to James Bown from The Northwood Trust.Drug ...
Bown, James, Goltsov, Alexey, Gregory Goltsov, Harrison, David J, Bown, J., Goltsov, Gregory, Simon P. Langdon, James eBown, Langdon, Simon P., Bown, James L., Langdon, S.P., Goltsov, G., Alexey eGoltsov, David eHarrison, Gregory eGoltsov, Alexey Goltsov, Harrison, D.J., Goltsov, A., Langdon, Simon P, David J. Harrison, Simon eLangdon, James Bown, Harrison, David J., Harrison, D.J.; id_orcid   +23 more
core   +1 more source

Dynamical Synergy of Drug Combinations during Cancer Chemotherapy

, 2022
Synergistic drug combinations often provide effective strategies to increase treatment efficacy and, during therapy, it is a time-dependent process. Data for colorectal and lung cancer in vivo were used for the phenomenological study of dynamical synergy
Martorana, Emanuele, Paolo Castorina, Emanuele Martorana, Forte, Stefano, Castorina, Paolo, Stefano Forte   +5 more
core   +1 more source

Eradication of Drug-Tolerant Mycobacterium tuberculosis 2022: Where We Stand

Microorganisms, 2023
The lungs of tuberculosis (TB) patients contain a spectrum of granulomatous lesions, ranging from solid and well-vascularized cellular granulomas to avascular caseous granulomas.
Alessio Lanni, Angelo Iacobino, Lanfranco Fattorini, Federico Giannoni   +3 more
doaj   +1 more source

Bifunctional antibiotic hybrids: A review of clinical candidates

Frontiers in Pharmacology, 2023
Antibiotic resistance is a top threat to human health and a priority across the globe. This problematic issue is accompanied by the decline of new antibiotics in the pipeline over the past 30 years.
Augustine Jing Jie Koh, Varsha Thombare, Maytham Hussein, Gauri G. Rao, Jian Li, Tony Velkov, Tony Velkov   +6 more
doaj   +1 more source

Activity of oxantel pamoate monotherapy and combination chemotherapy against Trichuris muris and hookworms : revival of an old drug [PDF]

, 2013
BACKGROUND: It is widely recognized that only a handful of drugs are available against soil-transmitted helminthiasis, all of which are characterized by a low efficacy against Trichuris trichiura, when administered as single doses.
Speich Benjamin, Tritten Lucienne, Jennifer Keiser, Speich, B., Keiser Jennifer, Benjamin Speich, Adelfio Roberto, Keiser, J., Adelfio, R., Tritten, L., Silbereisen Angelika, Vargas Mireille, Angelika Silbereisen, Roberto Adelfio, Silbereisen, A., Vargas, M., Lucienne Tritten, Mireille Vargas, Speich B, Keiser J, Tritten L, Adelfio R, Silbereisen A, Vargas M   +23 more
core   +2 more sources

Drug Prescription in the Department of Medicine of a Tertiary Care Hospital according to the World Health Organization/International Network for Rational Use of Drugs Core Indicators: A Descriptive Cross-sectional Survey

Journal of Nepal Medical Association, 2021
Introduction: To establish appropriate health care services in developing countries, rationalization of drug use holds utmost importance. Drug use patterns can be found out using Core Indicators of the World Health Organisation in collaboration with the ...
Jyoti Tara Manandhar Shrestha , Saurabh Tiwari, Dilip Kumar Kushwaha, Pratigya Bhattarai, Ruchi Shrestha   +4 more
doaj   +1 more source