NLLSS: Predicting Synergistic Drug Combinations Based on Semi-supervised Learning. [PDF]
PLoS Computational Biology, 2016 Fungal infection has become one of the leading causes of hospital-acquired infections with high mortality rates. Furthermore, drug resistance is common for fungus-causing diseases.
Xing Chen +5 more
doaj +1 more source
A network inference method for large-scale unsupervised identification of novel drug-drug interactions [PDF]
, 2013 Characterizing interactions between drugs is important to avoid potentially harmful combinations, to reduce off-target effects of treatments and to fight antibiotic resistant pathogens, among others.
Guimera, Roger, Sales-Pardo, Marta
core +4 more sources
Clinical development of new drug-radiotherapy combinations. [PDF]
, 2016 In countries with the best cancer outcomes, approximately 60% of patients receive radiotherapy as part of their treatment, which is one of the most cost-effective cancer treatments.
Adams, RA +39 more
core +13 more sources
Drug Interactions in Lenacapavir-Based Long-Acting Antiviral Combinations
Viruses, 2022 Long-acting (LA) anti-HIV regimens show promise for increasing dosing intervals and consequently, improving the patients’ quality of life. The first FDA-approved LA therapy is Cabenuva, which comprises rilpivirine (a non-nucleoside reverse transcriptase ...
Maria E. Cilento +3 more
doaj +1 more source
Combination of Dexmedetomidine with Bupivacaine versus Fentanyl with Bupivacaine Intrathecally for Prolongation of Postoperative Analgesia in Lower Limb Surgeries: A Randomised Clinical Study [PDF]
Journal of Clinical and Diagnostic ResearchIntroduction: Intrathecal adjuvants can be added to extend the duration of analgesia. To achieve this, several adjuvants, such as the combination of dexmedetomidine with bupivacaine versus fentanyl with bupivacaine, have been used with local anaesthesia ...
Arjun Peddapally +3 more
doaj +1 more source
Activity of oxantel pamoate monotherapy and combination chemotherapy against Trichuris muris and hookworms : revival of an old drug [PDF]
, 2013 BACKGROUND: It is widely recognized that only a handful of drugs are available against soil-transmitted helminthiasis, all of which are characterized by a low efficacy against Trichuris trichiura, when administered as single doses.
Adelfio, R. +5 more
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Long-term drug use and polypharmacy among the elderly population in the Republic of Srpska, Bosnia and Herzegovina [PDF]
Vojnosanitetski Pregled, 2016 Background/Aim. Prescription of drugs is a fundamental care component of the elderly. Elderly patients often take multiple drugs, and it is known that polypharmacy may lead to drug interactions and adverse events.
Marković-Peković Vanda, Škrbić Ranko
doaj +1 more source
Availability and affordability of treatment for Human African Trypanosomiasis. [PDF]
, 2001 Human African Trypanosomiasis (HAT) is a re-emerging disease whose usual treatments are becoming less efficient because of the increasing parasite resistance.
Etchegorry, M +4 more
core +3 more sources
Frontiers in Fungal Biology, 2021 Since the earliest days of using natural remedies, combining therapies for disease treatment has been standard practice. Combination treatments exhibit synergistic effects, broadly defined as a greater-than-additive effect of two or more therapeutic ...
Hamid Gaikani +6 more
doaj +1 more source
Rapid optimization of drug combinations for the optimal angiostatic treatment of cancer. [PDF]
, 2015 Drug combinations can improve angiostatic cancer treatment efficacy and enable the reduction of side effects and drug resistance. Combining drugs is non-trivial due to the high number of possibilities. We applied a feedback system control (FSC) technique
Berndsen, R.H. +15 more
core +4 more sources