Results 11 to 20 of about 793,626 (282)
Molecules, 2021 Despite Alzheimer’s disease (AD) incidence being projected to increase worldwide, the drugs currently on the market can only mitigate symptoms. Considering the failures of the classical paradigm “one target-one drug-one disease” in delivering effective ...
Claudia Albertini +7 more
doaj +1 more source
Candyflipping and Other Combinations: Identifying Drug–Drug Combinations from an Online Forum
Frontiers in Psychiatry, 2018 Novel psychoactive substances (NPS) refer to synthetic compounds or derivatives of more widely known substances of abuse that have emerged over the last two decades.
Michael Chary, David Yi, Alex F. Manini
doaj +1 more source
Understanding the Clinical Use of Levosimendan and Perspectives on its Future in Oncology
Biomolecules, 2023 Drug repurposing, also known as repositioning or reprofiling, has emerged as a promising strategy to accelerate drug discovery and development. This approach involves identifying new medical indications for existing approved drugs, harnessing the ...
Eduarda Ribeiro, Nuno Vale
doaj +1 more source
DRUG-NEM: Optimizing drug combinations using single-cell perturbation response to account for intratumoral heterogeneity. [PDF]
, 2018 An individual malignant tumor is composed of a heterogeneous collection of single cells with distinct molecular and phenotypic features, a phenomenon termed intratumoral heterogeneity.
Anchang, Benedict +8 more
core +1 more source
Synergistic drug combinations from electronic health records and gene expression. [PDF]
, 2016 ObjectiveUsing electronic health records (EHRs) and biomolecular data, we sought to discover drug pairs with synergistic repurposing potential. EHRs provide real-world treatment and outcome patterns, while complementary biomolecular data, including ...
Chen, William +19 more
core +2 more sources
Eradication of Drug-Tolerant Mycobacterium tuberculosis 2022: Where We Stand
Microorganisms, 2023 The lungs of tuberculosis (TB) patients contain a spectrum of granulomatous lesions, ranging from solid and well-vascularized cellular granulomas to avascular caseous granulomas.
Alessio Lanni +3 more
doaj +1 more source
Bifunctional antibiotic hybrids: A review of clinical candidates
Frontiers in Pharmacology, 2023 Antibiotic resistance is a top threat to human health and a priority across the globe. This problematic issue is accompanied by the decline of new antibiotics in the pipeline over the past 30 years.
Augustine Jing Jie Koh +6 more
doaj +1 more source
Multi-drug resistant Gram-negative bacteria: antibiotic-resistance and new treatment strategies [PDF]
, 2017 In this editorial, we treat the multi-drug-resistance of microorganisms such as Klebsiella pneumonia (Kp) and Acinetobacter baumanii and the issues concerning the management of these infections.
Angelis, Massimiliano De +2 more
core +1 more source
Prevalence and patterns of higher-order drug interactions in Escherichia coli. [PDF]
, 2018 Interactions and emergent processes are essential for research on complex systems involving many components. Most studies focus solely on pairwise interactions and ignore higher-order interactions among three or more components.
Cruz-Loya, Mauricio +7 more
core +2 more sources
Journal of Nepal Medical Association, 2021 Introduction: To establish appropriate health care services in developing countries, rationalization of drug use holds utmost importance. Drug use patterns can be found out using Core Indicators of the World Health Organisation in collaboration with the ...
Jyoti Tara Manandhar Shrestha +4 more
doaj +1 more source