Results 11 to 20 of about 2,669,018 (297)
Deciphering the Mechanisms of Statin–Ezetimibe Drug Combinations Using Boolean Logical Modeling and Transcriptomic Data [PDF]
CPT: Pharmacometrics & Systems PharmacologyDrug Combinations offer increased therapeutic efficacy and reduced toxicity compared with single agents. Understanding a drug combination's mechanisms of action (MoA) can provide important insights into therapeutic efficacy.
Rui‐Sheng Wang +5 more
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Network-based prediction of drug combinations
Nature Communications, 2019 Combination therapy holds great promise, but discovery remains challenging. Here, the authors propose a method to identify efficacious drug combinations for specific diseases, and find that successful combinations tend to target separate neighbourhoods ...
Feixiong Cheng +2 more
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Drug Combinations: Mathematical Modeling and Networking Methods
Pharmaceutics, 2019 Treatments consisting of mixtures of pharmacological agents have been shown to have superior effects to treatments involving single compounds. Given the vast amount of possible combinations involving multiple drugs and the restrictions in time and ...
Vahideh Vakil, Wade Trappe
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Drug combinations targeting antibiotic resistance [PDF]
npj Antimicrobials and ResistanceWhile the rise of antibiotic resistance poses a global health challenge, the development of new antibiotics has slowed down over the past decades. This turned the attention of researchers towards the rational design of drug combination therapies to ...
Bence Bognár +2 more
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Identification and Tracking of Antiviral Drug Combinations
Viruses, 2020 Combination therapies have become a standard for the treatment for HIV and hepatitis C virus (HCV) infections. They are advantageous over monotherapies due to better efficacy, reduced toxicity, as well as the ability to prevent the development of ...
Aleksandr Ianevski +25 more
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Guided screen for synergistic three-drug combinations.
PLoS ONE, 2020 Combinations of three or more drugs are routinely used in various medical fields such as clinical oncology and infectious diseases to prevent resistance or to achieve synergistic therapeutic benefits.
Melike Cokol-Cakmak +4 more
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Leishmania donovani develops resistance to drug combinations. [PDF]
PLoS Neglected Tropical Diseases, 2012 Drug combinations for the treatment of leishmaniasis represent a promising and challenging chemotherapeutic strategy that has recently been implemented in different endemic areas.
Raquel García-Hernández +3 more
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Novel Synergistic Anti-Enteroviral Drug Combinations
Viruses, 2022 Background: Enterovirus infections affect people around the world, causing a range of illnesses, from mild fevers to severe, potentially fatal conditions. There are no approved treatments for enterovirus infections. Methods: We have tested our library of
Aleksandr Ianevski +7 more
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Oncology drug-companion diagnostic combinations
Cancer Treatment and Research Communications, 2021 With the development of trastuzumab for metastatic breast cancer a new era began in cancer drug development. The drug-diagnostic codevelopment model with its clinical enrichment trial design has enabled development of target specific drugs for molecular ...
Jan Trøst Jørgensen
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Respiratory Medicine Case Reports, 2022 The effective therapy for pulmonary arterial hypertension (PAH) with inadequate clinical response is scarce except for lung transplantation when prostacyclin infusion is ineffective.
Mizuki Momoi +7 more
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