Results 61 to 70 of about 737,831 (320)

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Clinical development of new drug-radiotherapy combinations. [PDF]

, 2016
In countries with the best cancer outcomes, approximately 60% of patients receive radiotherapy as part of their treatment, which is one of the most cost-effective cancer treatments.
Adams, RA, Ataman, O, Baird, RD, Billingham, L, Brown, SR, Buckland, S, Bulbeck, H, Chalmers, AJ, Clack, G, Clay, R, Cranston, AN, Damstrup, L, Ferraldeschi, R, Forster, MD, Golec, J, Greenhalgh, TA, Hagan, RM, Hall, E, Hanauske, AR, Harrington, KJ, Haswell, T, Hawkins, MA, Illidge, T, Jones, H, Kelly, S, Kennedy, AS, McDonald, F, Melcher, T, NCRI CTRad Academia-Pharma Joint Working Group, O'Connor, JP, Plummer, R, Pollard, JR, Saunders, MP, Sebag-Montefiore, D, Sharma, RA, Smitt, M, Staffurth, J, Stock, JK, Stratford, IJ, Wedge, SR   +39 more
core   +9 more sources

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Mechanism-Independent Method for Predicting Response to Multidrug Combinations in Bacteria [PDF]

, 2014
Drugs are commonly used in combinations larger than two for treating bacterial infection. However, it is generally impossible to infer directly from the effects of individual drugs the net effect of a multidrug combination.
Cluzel, Philippe, Nishida, Satoshi, Sontag, Eduardo D., Wood, Kevin   +3 more
core   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Changes in kidney function in a population with essential hypertension in real life settings [PDF]

, 2017
Introduction. Hypertension has been identified as one of the commonest modifiable determinants for chronic kidney disease progression. A variety of antihypertensive drugs are available and their effect on kidney function has been investigated by a ...
Haidich, Anna-Bettina, Lasaridis, Anastasios N., Mark, Patrick B., Pikilidou, Maria I., Ptinopoulou, Anastasia G., Tziolas, Ioannis M., Zebekakis, Pantelis E.   +6 more
core  

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Identification and Tracking of Antiviral Drug Combinations

Viruses, 2020
Combination therapies have become a standard for the treatment for HIV and hepatitis C virus (HCV) infections. They are advantageous over monotherapies due to better efficacy, reduced toxicity, as well as the ability to prevent the development of ...
Aleksandr Ianevski, Rouan Yao, Svetlana Biza, Eva Zusinaite, Andres Mannik, Gaily Kivi, Anu Planken, Kristiina Kurg, Eva-Maria Tombak, Mart Ustav, Nastassia Shtaida, Evgeny Kulesskiy, Eunji Jo, Jaewon Yang, Hilde Lysvand, Kirsti Løseth, Valentyn Oksenych, Per Arne Aas, Tanel Tenson, Astra Vitkauskienė, Marc P. Windisch, Mona Høysæter Fenstad, Svein Arne Nordbø, Mart Ustav, Magnar Bjørås, Denis E. Kainov   +25 more
doaj   +1 more source

SynergyFinder : a web application for analyzing drug combination dose-response matrix data [PDF]

, 2017
Rational design of drug combinations has become a promising strategy to tackle the drug sensitivity and resistance problem in cancer treatment. To systematically evaluate the preclinical significance of pairwise drug combinations, functional screening ...
Al-Lazikani, Aleksandr Ianevski, Berenbaum, Bliss, Di Veroli, Jing Tang, Knight, Liye He, Loewe, Mathews Griner, Mott, Oliver Stegle, Tang, Tero Aittokallio, Yadav   +14 more
core   +1 more source