Results 91 to 100 of about 1,750,852 (307)
The burden of malaria in East Africa: prevalence, risk factors, and control strategies
Malaria JournalBackground Malaria continues to exert a severe toll on public health in East Africa, accounting for a large share of global morbidity and mortality. Despite national strategies and donor-funded efforts, the disease persists due to complex, intersecting ...
Sharmake Gaiye Bashir +5 more
doaj +1 more source
Public health advocacy for the Berlin Declaration on tuberculosis in the former Soviet Union: the view of Médecins Sans Frontières [PDF]
, 2012 To assist international efforts to address major gaps in the availability and accessibility of quality diagnosis and treatment for multi-drug resistant tuberculosis, Médecins Sans Frontières has adapted an approach combining three sets of interlinked ...
Balabanova D. +6 more
core +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Drug selection based on pan-genomics genetic features of Mycobacterium tuberculosis
Frontiers in MicrobiologyTuberculosis, caused by Mycobacterium tuberculosis, is a severe and persistent global public health issue, particularly exacerbated by the emergence of multidrug-resistant and extensively drug-resistant strains. This study employed pan-genomic approaches
Xiangcheng Sun +4 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
ACT Now or Later: The Economics of Malaria Resistance [PDF]
In the past, malaria control efforts in sub-Saharan Africa have relied on a combination of vector control and effective treatment using chloroquine. With increasing resistance to chloroquine, attention has now turned to alternative treatment strategies ...
Laxminarayan, Ramanan
core
Control of infection dynamics, with applications to the HIV disease
, 2009 The human immunodeficiency virus (HIV) infection, that causes acquired immune deficiency syndrome (AIDS), is a dynamic process that can be modeled via differential equations.
Chang, Hyeygjeon, Chang, Hyeygjeon
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
GelsDual-drug delivery systems using hydrogel–nanoparticle composites have emerged as a versatile platform for achieving controlled, targeted, and efficient delivery of two distinct therapeutic agents.
Moon Sup Yoon +12 more
doaj +1 more source
Prevention strategies for substance use disorders in low-resource settings
Indian Journal of Social Psychiatry, 2017 Substance use continues to be a major public health problem for the low- and middle-income countries (LMICs) around the world. Prevention strategies, which are theoretically grounded, culturally sensitive, and cost effective, can help such resource ...
Koushik Sinha Deb, Swati Kedia Gupta
doaj +1 more source