Altered drug susceptibility during host adaptation of a Plasmodium falciparum strain in a non-human primate model [PDF]
, 2016 Infections with Plasmodium falciparum, the most pathogenic of the Plasmodium species affecting man, have been reduced in part due to artemisinin-based combination therapies.
Baro, Nicholas +14 more
core +1 more source
Impact of Mobility on Methicillin-Resistant Staphylococcus aureus among Injection Drug Users
Antibiotics, 2019 In this study, we develop and present a deterministic model for the transmission dynamics of methicillin-resistant staphylococcus aureus (MRSA) among injection drug users.
Folashade B. Agusto, Soyeon Kim
doaj +1 more source
How can onchocerciasis elimination in Africa be accelerated? Modelling the impact of increased ivermectin treatment frequency and complementary vector control [PDF]
, 2017 Background: Great strides have been made toward onchocerciasis elimination by mass drug administration (MDA) of ivermectin. Focusing on MDA-eligible areas, we investigated where the elimination goal can be achieved by 2025 by continuation of current ...
Afework H Tekle +59 more
core +5 more sources
The Visibility of Illicit Drugs: Implications for Community-Based Drug Control Strategies
American Journal of Public Health, 2001 Objectives. This study examined differences between the visibility of drugs and drug use in more than 2100 neighborhoods, challenging an assumption about drug use in poor, minority, and urban communities. Methods. A telephone survey assessed substance use and attitudes across 41 communities in an evaluation of a national community-based demand ...
L, Saxe +7 more
openaire +3 more sources
Antibiotic Adjuvants: Diverse Strategies for Controlling Drug‐Resistant Pathogens [PDF]
Chemical Biology & Drug Design, 2014 The growing number of bacterial pathogens that are resistant to numerous antibiotics is a cause for concern around the globe. There have been no new broad‐spectrum antibiotics developed in the last 40 years, and the drugs we have currently are quickly becoming ineffective.
Gill, Erin E +2 more
openaire +2 more sources
Identification of control targets in Boolean molecular network models via computational algebra [PDF]
, 2016 Motivation: Many problems in biomedicine and other areas of the life sciences can be characterized as control problems, with the goal of finding strategies to change a disease or otherwise undesirable state of a biological system into another, more ...
Aguilar, Boris +3 more
core +5 more sources
Subgroup identification in dose-finding trials via model-based recursive partitioning [PDF]
, 2018 An important task in early phase drug development is to identify patients, which respond better or worse to an experimental treatment. While a variety of different subgroup identification methods have been developed for the situation of trials that study
Bornkamp, Björn +2 more
core +1 more source
Parasite Epidemiology and Control, 2022 Malaria is one of the prevalent tropical diseases caused by the parasitic protozoan of the genus Plasmodium spp. With an estimated 228 million cases, it is a major public health concern with high incidence of morbidity and mortality worldwide.
Lohitha Gujjari +4 more
doaj +1 more source
Metformin Decreases the Incidence of Pancreatic Ductal Adenocarcinoma Promoted by Diet-induced Obesity in the Conditional KrasG12D Mouse Model. [PDF]
, 2018 Pancreatic ductal adenocarcinoma (PDAC) is a particularly deadly disease. Chronic conditions, including obesity and type-2 diabetes are risk factors, thus making PDAC amenable to preventive strategies.
Chang, Hui-Hua +10 more
core +2 more sources
The transcriptome of Mycobacterium tuberculosis in a lipid-rich dormancy model through RNAseq analysis [PDF]
, 2017 Tuberculosis (TB) is currently the number one killer among infectious diseases worldwide. Lipids are abundant molecules during the infectious cycle of Mycobacterium tuberculosis (Mtb) and studies better mimicking its actual metabolic state during ...
Aguilar-Ayala, Diana +7 more
core +2 more sources