Results 41 to 50 of about 1,750,852 (307)

Malaria’s molecular dance: Mechanism, therapies, and emerging insights [PDF]

Pharmacia
Malaria, caused by Plasmodium parasites and transmitted through Anopheles mosquitoes, remains a formidable global health challenge. This abstract provides an overview of the intricate molecular mechanisms underlying malaria pathogenesis, explores current
Nabila Ananda, Athaya Sabina, Ulfa Rahmadani, Ali Syahrizal, Nabillah Deskya, Sinta Maria, Muhammad Riza, Lusi Rahmadia, Anni Holila, Dwi Putri, Kevin Gabriel, Ratna Sari Zai, Mega Carensia, Princella Halim, Naomi Regina, Dinda Rizka, Aulia Syahfitri, Tessa Rotua, Maria Belen, Fahmy Nanda, Rizzanda Pramuditya, Khairunnisa Khairunnisa, Emil Salim, Fahrul Nurkolis, Chindy Umaya, Rony Abdi Syahputra   +25 more
doaj   +3 more sources

Review on Bioinspired Design of ECM-Mimicking Scaffolds by Computer-Aided Assembly of Cell-Free and Cell Laden Micro-Modules

Journal of Functional Biomaterials, 2023
Tissue engineering needs bioactive drug delivery scaffolds capable of guiding cell biosynthesis and tissue morphogenesis in three dimensions. Several strategies have been developed to design and fabricate ECM-mimicking scaffolds suitable for directing in
Aurelio Salerno, Paolo Antonio Netti
doaj   +1 more source

Pharmacogenetics of type 2 diabetes mellitus, the route toward tailored medicine [PDF]

, 2019
Type 2 diabetes mellitus (T2DM) is a chronic disease that has reached the levels of a global epidemic. In order to achieve optimal glucose control, it is often necessary to rely on combination therapy of multiple drugs or insulin because uncontrolled ...
Andreozzi, F, Mannino, Gc, Sesti, G
core   +1 more source

Emergence of Increased Resistance and Extensively Drug-Resistant Tuberculosis Despite Treatment Adherence, South Africa

Emerging Infectious Diseases, 2010
We investigated the emergence and evolution of drug-resistant tuberculosis (TB) in an HIV co-infected population at a South African gold mine with a well-functioning TB control program. Of 128 patients with drug-resistant TB diagnosed during January 2003–
Alistair D. Calver, Alecia A. Falmer, Megan B. Murray, Odelia J. Strauss, Elizabeth M. Streicher, Madelene Hanekom, Thelma Liversage, Mothusi Masibi, Paul D. van Helden, Robin M. Warren, Thomas C. Victor   +10 more
doaj   +1 more source

Mathematical Modeling and Optimal Control Strategy for a Discrete Time Drug Consumption Model

Discrete Dynamics in Nature and Society, 2020
The aim of this paper is to study and investigate the optimal control strategy of a discrete mathematical model of drug consumption. The population that we are going to study is divided into six compartments: potential drug users, light drug users, heavy
Abderrahim Labzai, Abdelfatah Kouidere, Bouchaib Khajji, Omar Balatif, Mostafa Rachik   +4 more
doaj   +1 more source

CMC development of [14C]-labeled sotorasib for the conduct of microtracer human ADME study

AAPS Open, 2023
Human absorption, distribution, metabolism, and excretion (hADME) studies of new drugs are required for global regulatory filings. Recent advances in high sensitivity analytical technologies have enabled microtracer hADME studies wherein very low ...
Sonika Sharma, Prashant Agarwal, Andrew T. Parsons, James E. Huckle, Tiffany L. Correll   +4 more
doaj   +1 more source

Optimal population-level infection detection strategies for malaria control and elimination in a spatial model of malaria transmission

, 2015
Mass campaigns with antimalarial drugs are potentially a powerful tool for local elimination of malaria, yet current diagnostic technologies are insufficiently sensitive to identify all individuals who harbor infections.
Bever, Caitlin A., Eckhoff, Philip A., Gerardin, Jaline, Hamainza, Busiku, Miller, John M., Wenger, Edward A.   +5 more
core   +3 more sources

Electrospun nanofibres in drug delivery: advances in controlled release strategies

RSC Advances, 2023
Various approaches to control the release of active molecules or drug molecules through electrospun polymeric nanofibers.
Mrunalini K. Gaydhane, Chandra Shekhar Sharma, Saptarshi Majumdar   +2 more
openaire   +3 more sources

Job stress and depression among Malaysian anti-drug professionals: The moderating role of job-related coping strategies

Frontiers in Psychiatry, 2022
Depression can cause negative consequences to workers' health and social functioning, such as poor work productivity, mental disorders, and suicide. Existing studies have argued that job stress is closely related to depression in many professions.
Noradilah Md Nordin, Naqi Dahamat Azam, Mohd Roslan Rosnon, Mansor Abu Talib   +3 more
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source