Results 101 to 110 of about 6,817,458 (407)

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Anticancer drug delivery with transferrin targeted polymeric chitosan vesicles [PDF]

, 2004
The study reports the initial biological evaluation of targeted polymeric glycol chitosan vesicles as carrier systems for doxorubicin (Dox). Transferrin (Tf) was covalently bound to the Dox-loaded palmitoylated glycol chitosan (GCP) vesicles using ...
Couet, William, Dufès, Christine, Muller, Jean-Marc, Olivier, Jean-Christophe, Schätzlein, Andreas G., Uchegbu, I.F.   +5 more
core   +1 more source

Nanoparticle-Based Drug Delivery in Cancer Therapy and Its Role in Overcoming Drug Resistance

Frontiers in Molecular Biosciences, 2020
Nanotechnology has been extensively studied and exploited for cancer treatment as nanoparticles can play a significant role as a drug delivery system.
Yihan Yao, Yunxiang Zhou, Lihong Liu, Yanyan Xu, Qiang Chen, Yali Wang, Shijie Wu, Yongchuan Deng, Jianmin Zhang, Anwen Shao   +9 more
semanticscholar   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Targeted delivery of celastrol to mesangial cells is effective against mesangioproliferative glomerulonephritis

Nature Communications, 2017
Mesangial cell-mediated glomerulonephritis is a frequent cause of kidney disease. Here the authors show that celastrol loaded in albumin nanoparticles efficiently targets mesangial cells, and is effective in rat models.
Ling Guo, Shi Luo, Zhengwu Du, Meiling Zhou, Peiwen Li, Yao Fu, Xun Sun, Yuan Huang, Zhirong Zhang   +8 more
doaj   +1 more source

Investigation of the Transport Pathways Associated with Enhanced Brain Delivery of Peptide Drugs by Intranasal Coadministration with Penetratin [PDF]

, 2021
Noriyasu Kamei, Susumu Suwabe, Kenji Arime, Hidemi Bando, Kaho Murata, Maika Yamaguchi, Natsuki Yokoyama, Erina Tanaka, Ayaka Hashimoto, Takanori Kanazawa, Yukio Ago, Mariko Takeda‐Morishita   +11 more
openalex   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

3D conformation and crystal interaction insights into drug development challenges for HCV drug analogues via molecular simulations

Communications Chemistry
ABT-333 and ABT-072 are two potent non-nucleoside NS5B polymerase inhibitors designed for the treatment of the hepatitis C virus (HCV). These structural analogs differ only by a minor substituent change, which disrupts the planarity of the naphthyl group
Richard S. Hong, Alessandra Mattei, Mark E. Tuckerman, Ahmad Y. Sheikh   +3 more
doaj   +1 more source

Soluplus solutions as thermothickening materials for topical drug delivery. [PDF]

, 2019
Soluplus is a pharmaceutical excipient used primarily in the manufacture of solid dispersions. The polymer also exhibits interesting rheology in aqueous solution, increasing in viscosity as the solution is warmed.
Abou Shamat, Mohamad, Cook, Michael
core   +2 more sources

Metal–Organic Framework Nanocarriers for Drug Delivery in Biomedical Applications

Nano-Micro Letters, 2020
Recent advances in biomedical applications of metal–organic framework (MOF) nanocarriers for drug delivery are summarized. State-of-the-art strategies to functionalize MOFs with therapeutic agents, as well as their merits and drawbacks, are ...
Yujia Sun, Liwei Zheng, Yu Yang, X. Qian, Ting Fu, Xiaowei Li, Zunyi Yang, He Yan, Cheng Cui, W. Tan   +9 more
semanticscholar   +1 more source