Results 71 to 80 of about 1,046,273 (215)
Influence of verapamil on the pharmacokinetics of rotundic acid in rats and its potential mechanism
Pharmaceutical Biology, 2021 Context Rotundic acid (RA), a plant-derived pentacyclic triterpene acid, has been reported to possess extensive pharmacological activities. The poor bioavailability limits its further development and potential clinic application. Objective To clarify the
Haihua Shang +7 more
doaj +1 more source
Advanced Technologies for Oral Controlled Release: Cyclodextrins for oral controlled release [PDF]
, 2011 Cyclodextrins (CDs) are used in oral pharmaceutical formulations, by means of inclusion complexes formation, with the following advantages for the drugs: (1) solubility, dissolution rate, stability and bioavailability enhancement; (2) to modify the drug ...
A Al-Omar +153 more
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Pharmaceutics, 2023 The current research aims to improve the solubility of the poorly soluble drug, i.e., ibuprofen, by developing self-emulsifying drug delivery systems (SEDDS) utilizing a twin screw melt granulation (TSMG) approach.
Dinesh Nyavanandi +6 more
doaj +1 more source
The use of heat and chemical penetration enhancers to increase the follicular delivery of erythromycin to the skin [PDF]
, 2020 Copyright © 2019. Published by Elsevier B.V.The effect of heat on the follicular absorption of drugs into the skin has not previously been investigated.
Akomeah +42 more
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Novel Pharmaceutical Strategies for Enhancing Skin Penetration of Biomacromolecules
Pharmaceuticals, 2022 Skin delivery of biomacromolecules holds great advantages in the systemic and local treatment of multiple diseases. However, the densely packed stratum corneum and the tight junctions between keratinocytes stand as formidable skin barriers against the ...
Luyu Zhang +7 more
doaj +1 more source
Validation of smart nanoparticles as controlled drug delivery systems: loading and pH-dependent release of pilocarpine [PDF]
, 2017 Micelles are good devices for use as controlled drug delivery systems because they exhibit the ability to protect the encapsulated substance from the routes of degradation until they reach the site of action. The present work assesses loading kinetics of
Galbis Fuster, Elsa +4 more
core +2 more sources
Drug Delivery and Translational Research, 2012 The nasal cavity has for more than three decades been widely explored as a potential alternative route to oral or parenteral administration for systemically active drugs. The nasal route has shown remarkable advantages that include a rapid and high systemic availability, avoidance of first pass metabolism by the liver, and the possibility of targeting ...
Lisbeth Illum, Elka Touitou
openaire +3 more sources
Nature Communications, 2017 Mesangial cell-mediated glomerulonephritis is a frequent cause of kidney disease. Here the authors show that celastrol loaded in albumin nanoparticles efficiently targets mesangial cells, and is effective in rat models.
Ling Guo +8 more
doaj +1 more source
Diffusive Mobile MC for Controlled-Release Drug Delivery with Absorbing Receiver [PDF]
arXiv, 2018 Nanoparticle drug carriers play an important role in facilitating efficient targeted drug delivery, i.e., improving treatment success and reducing drug costs and side effects. However, the mobility of nanoparticle drug carriers poses a challenge in designing drug delivery systems.
arxiv
Human Vault Nanoparticle Targeted Delivery of Antiretroviral Drugs to Inhibit Human Immunodeficiency Virus Type 1 Infection. [PDF]
, 2019 "Vaults" are ubiquitously expressed endogenous ribonucleoprotein nanoparticles with potential utility for targeted drug delivery. Here, we show that recombinant human vault nanoparticles are readily engulfed by certain key human peripheral blood ...
Anton, Peter A +11 more
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