Results 61 to 70 of about 903,949 (317)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Head‐to‐head comparison between ACQ and FRET in probing polymeric micelles

View
Environmentally responsive fluorophores, such as those with aggregation‐caused quenching (ACQ) and Förster resonance energy transfer (FRET) properties, are widely used to track nanocarriers while minimizing artifacts.
Runtong Zhang, Chang Liu, Ruonan Lu, Yuanmei Yang, Zichen Zhang, Yifan Cai, Haisheng He, Yi Lu, Aun Raza, Wei Wu   +9 more
doaj   +1 more source

Combining MucilAir™ and Vitrocell® Powder Chamber for the In Vitro Evaluation of Nasal Ointments in the Context of Aerosolized Pollen

Pharmaceutics, 2018
Hay fever is notoriously triggered when nasal mucosa is exposed to allergenic pollen. One possibility to overcome this pollen exposure may be the application of an ointment with physical protective effects. In this context, we have investigated Bepanthen&
Julia Metz, Katharina Knoth, Henrik Groß, Claus-Michael Lehr, Carolin Stäbler, Udo Bock, Marius Hittinger   +6 more
doaj   +1 more source

Accurate and sensitive probing of onset of micellization based on absolute aggregation‐caused quenching effect

Aggregate, 2022
Probing the onset of micellization, or determining the critical micelle concentration (CMC), is of crucial importance while remains to be challenged by growing demand for extraordinary sensitivity and accuracy.
Haisheng He, Chang Liu, Jiang Ming, Yongjiu Lv, Jianping Qi, Yi Lu, Xiaochun Dong, Weili Zhao, Wei Wu   +8 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Microfabrication for Drug Delivery [PDF]

Materials, 2016
This review is devoted to discussing the application of microfabrication technologies to target challenges encountered in life processes by the development of drug delivery systems. Recently, microfabrication has been largely applied to solve health and pharmaceutical science issues.
Brendan Koch, Ilaria Rubino, Fu-Shi Quan, Bongyoung Yoo, Hyo-Jick Choi   +4 more
openaire   +2 more sources

Cell-Based Drug Delivery Platforms

, 2020
Within the framework of nanomedicine, drug delivery has experienced rapid progress in recent years [...
Carmen Gutiérrez-Millán, José M. Lanao, Clara I. Colino   +2 more
core   +1 more source

Hydrogel Drug Delivery Systems for Bone Regeneration

, 2023
With the in-depth understanding of bone regeneration mechanisms and the development of bone tissue engineering, a variety of scaffold carrier materials with desirable physicochemical properties and biological functions have recently emerged in the field ...
Jingang Xiao, Yuping Xie, Maogeng Feng, Gang Tao, Shuyu Cai, Shuanglin Peng, Long Bai   +6 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Targeted delivery of celastrol to mesangial cells is effective against mesangioproliferative glomerulonephritis

Nature Communications, 2017
Mesangial cell-mediated glomerulonephritis is a frequent cause of kidney disease. Here the authors show that celastrol loaded in albumin nanoparticles efficiently targets mesangial cells, and is effective in rat models.
Ling Guo, Shi Luo, Zhengwu Du, Meiling Zhou, Peiwen Li, Yao Fu, Xun Sun, Yuan Huang, Zhirong Zhang   +8 more
doaj   +1 more source