Results 41 to 50 of about 770,951 (120)

Accurate and sensitive probing of onset of micellization based on absolute aggregation‐caused quenching effect

Aggregate, 2022
Probing the onset of micellization, or determining the critical micelle concentration (CMC), is of crucial importance while remains to be challenged by growing demand for extraordinary sensitivity and accuracy.
Haisheng He, Chang Liu, Jiang Ming, Yongjiu Lv, Jianping Qi, Yi Lu, Xiaochun Dong, Weili Zhao, Wei Wu   +8 more
doaj   +1 more source

3D conformation and crystal interaction insights into drug development challenges for HCV drug analogues via molecular simulations

Communications Chemistry
ABT-333 and ABT-072 are two potent non-nucleoside NS5B polymerase inhibitors designed for the treatment of the hepatitis C virus (HCV). These structural analogs differ only by a minor substituent change, which disrupts the planarity of the naphthyl group
Richard S. Hong, Alessandra Mattei, Mark E. Tuckerman, Ahmad Y. Sheikh   +3 more
doaj   +1 more source

Guiding a Diclofenac Sodium Dual-Release Sustained Formulation Development Through In Vitro–In Vivo Relationship Based on Physiologically Based Pharmacokinetics

Pharmaceutics
Background: Dual-release sustained formulations enable rapid drug release for prompt therapeutic onset while retaining the characteristics of sustained-release dosage forms. However, due to the complexity of this dosage form, conventional trial-and-error
Qizheng Wang, Pengcheng Guo, Tianci Hu, Longjie Li, Tingxi Zhu, Yue Pan, Xiaoqiang Xiang, Jianxin Wang   +7 more
doaj   +1 more source

Targeted delivery of celastrol to mesangial cells is effective against mesangioproliferative glomerulonephritis

Nature Communications, 2017
Mesangial cell-mediated glomerulonephritis is a frequent cause of kidney disease. Here the authors show that celastrol loaded in albumin nanoparticles efficiently targets mesangial cells, and is effective in rat models.
Ling Guo, Shi Luo, Zhengwu Du, Meiling Zhou, Peiwen Li, Yao Fu, Xun Sun, Yuan Huang, Zhirong Zhang   +8 more
doaj   +1 more source

Advances in Medical Devices for Augmented Acupuncture Therapy

Advanced Science
Acupuncture, as a traditional medicine applied worldwide, is considered an effective treatment for numerous chronic diseases. Many researches have explored the biological mechanisms of acupuncture, including the skin‐neuro‐immune axis and inflammation ...
Ruisi Cai, Chenyi Yu, Xinyi Luo, Ningyu Xu, Jicheng Yu, Xiao Ye, Yuqi Zhang, Zhen Gu   +7 more
doaj   +1 more source

Modulating nuclear stiffness and envelope barrier facilitates AAV nuclear entry and reduces immunogenicity

Nature Communications
Recombinant adeno-associated viruses (rAAVs) have shown promise for orthopedic diseases. However, conventional AAV vectors face major challenges, where immune responses reduce transgene efficacy and inadequate vector potency requires higher doses ...
Yangsen Ou, Fuhua Wu, Chunting He, Shuang Luo, Zhaofei Guo, Yongshun Zhang, Rui Hu, Yanhua Xu, Xue Tang, Yuanhao Zhao, Lin Ye, Xiaoyan Chen, Shuting Bai, Guangsheng Du, Xun Sun   +14 more
doaj   +1 more source

Activation of glial cells induces proinflammatory properties in brain capillary endothelial cells in vitro

Scientific Reports
Neurodegenerative diseases are often accompanied by neuroinflammation and impairment of the blood-brain barrier (BBB) mediated by activated glial cells through their release of proinflammatory molecules. To study the effects of glial cells on mouse brain
Annette Burkhart, Steinunn Sara Helgudóttir, Yahye A. Mahamed, Mikkel B. Fruergaard, Julie N. Holm-Jacobsen, Hulda Haraldsdóttir, Sara E. Dahl, Freja Pretzmann, Lisa Greve Routhe, Kate Lambertsen, Torben Moos, Maj Schneider Thomsen   +11 more
doaj   +1 more source

Particle Size Affects Concentration-Dependent Cytotoxicity of Chitosan Nanoparticles towards Mouse Hematopoietic Stem Cells

Journal of Nanotechnology, 2015
Chitosan nanoparticles (CSNPs) have been extensively applied in medical and pharmaceutical fields as promising drug delivery systems. Despite that, the safety of CSNPs remains inadequate and needs further investigation, particularly on hematopoietic stem
Siti Sarah Omar Zaki, Mohd Nazmi Ibrahim, Haliza Katas   +2 more
doaj   +1 more source

Efficacy and safety of anti-prediabetic drugs in patients with prediabetes: a Bayesian network meta-analysis

BMC Medicine
Background Prediabetes refers to the transitional stage from normal glucose metabolism to diabetes. The International Diabetes Federation guidelines reported that, as of 2024, approximately 1.12 billion people globally were in the prediabetes stage ...
Yike Wu, Zihan Wang, Adili Tuersun, Qiuxia Yu, Yu Zhong, Shah Syed Alfakhar Ali, Haiyang Liu, Xinyi Hu, Yanfei Zhang, Liyuan Pang, Longzhou Li, Long Gao, Qiwen Wu, Shan Wang, Meng Cui, Linglu Sun, Yulin Wu, Antong Yin, Lei Zhang, Guo Ma   +19 more
doaj   +1 more source

Role of size, surface charge, and PEGylated lipids of lipid nanoparticles (LNPs) on intramuscular delivery of mRNA

Journal of Nanobiotechnology
Lipid nanoparticles (LNPs) are currently the most commonly used non-viral gene delivery system. Their physiochemical attributes, encompassing size, charge and surface modifications, significantly affect their behaviors both in vivo and in vitro ...
Weiwen Kong, Yuning Wei, Zirong Dong, Wenjuan Liu, Jiaxin Zhao, Yan Huang, Jinlong Yang, Wei Wu, Haisheng He, Jianping Qi   +9 more
doaj   +1 more source