Results 31 to 40 of about 903,949 (317)

Engineering the drug carrier biointerface to overcome biological barriers to drug delivery [PDF]

, 2020
Micro and nanoscale drug carriers must navigate through a plethora of dynamic biological systems prior to reaching their tissue or disease targets.
Finbloom, Joel A, Stevens, Molly M, Sousa, Flávia, Desai, Tejal A   +3 more
core   +1 more source

Micro and nanoscale technologies in oral drug delivery [PDF]

, 2020
Oral administration is a pillar of the pharmaceutical industry and yet it remains challenging to administer hydrophilic therapeutics by the oral route.
Nasiri, R, Hosseini, Vahid, Nasrollahi, F, Desai, Tejal A., Mofidfar, Mohammad, Khademhosseini, Ali, Nasrollahi, Fatemeh, Finbloom, JA, Montazerian, Hossein, Montazerian, H, Stevens, Molly M, Ahadian, S, Davoodi, E, Nasiri, Rohollah, Fetah, K, Stevens, Molly M., Emir Diltemiz, Sibel, Sangabathuni, S, Dokmeci, Mehmet Remzi, Finbloom, Joel A, Diltemiz, Sibel Emir, Stevens, Molly, Finbloom, Joel A., Desai, TA, Ahadian, Samad, Mofidfar, M, Hosseini, V, Davoodi, Elham, Sangabathuni, Sivakoti, Fetah, Kirsten, Mylonaki, Ioanna, Desai, Tejal A, Khademhosseini, A, Remzi Dokmeci, Mehmet, Mylonaki, I, Remzi Dokmeci, M   +35 more
core   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

The Role of Oral Controlled Release Matrix Tablets in Drug Delivery Systems [PDF]

, 2012
Formulations that are able to control the release of drug have become an integral part of the pharmaceutical industry. In particular oral drug delivery has been the focus of pharmaceutical research for many years.
Raja, Shaista, Ali Nokhodchi, Shaista Raja, Pryia Patel, Asare-Addo, Kofi, Patel, Pryia, Kofi Asare-Addo, Shaista Raja (16203524), Nokhodchi, Ali, Priya Patel (679595), Ali Nokhodchi (4465915), Kofi Asare-Addo (4172488)   +11 more
core   +1 more source

Hospitalization Through Families’ Eyes: Comparing Inpatient Care Quality for Children With Sickle Cell Disease and Cystic Fibrosis in Canada

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a chronic, inherited hemoglobinopathy that requires frequent hospitalization for disease‐related complications. Canadian data on inpatient care is limited. This study compared caregiver‐reported hospital experiences of children with SCD to those with cystic fibrosis (CF), a chronic, autosomal recessive ...
Hailey M. Zwicker, Kyle Kemp, Perri Tutelman, Sharon H. J. Hou, Paul Fairie, Maria Santana, Gregory M. T. Guilcher, Taryn Fay‐McClymont, Glenda Bendiak, Wendy Pelletier, Nicola Wright, Fiona Schulte   +11 more
wiley   +1 more source

Lyophilized monoclonal antibody (mAb) encoded mRNA—lipid nanoparticles (LNPs) lead to stable in vivo expression of mAb after room temperature storage

AAPS Open
The recent success of mRNA COVID-19 vaccines using lipid nanoparticles (LNPs) underscores the potential of this technology for delivering gene-encoded biologics in humans.
Zimeng Wang, Bei Cheng, Christine Tkaczyk, Michael Newton, Shuolin Cui, Bohdan Andreiuk, Sanjib Saha, Sabrina Khan, Charles Chen, Bin Yang, Adam Gamson, Sarah Siddiqui, George Thom, Antonio DiGiandomenico, Liping Zhou   +14 more
doaj   +1 more source

A Historical Review of Brain Drug Delivery

, 2022
The history of brain drug delivery is reviewed beginning with the first demonstration, in 1914, that a drug for syphilis, salvarsan, did not enter the brain, due to the presence of a blood–brain barrier (BBB). Owing to restricted transport across the BBB,
Pardridge, William M., William M. Pardridge   +1 more
core   +1 more source

Claudin‐6 Protein Expression in Atypical Teratoid/Rhabdoid Tumors Is Strongly Enriched in the Molecular Subgroup AT/RT‐TYR

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke, Christian Thomas, Michael C. Frühwald, Pascal D. Johann, Martin Hasselblatt   +4 more
wiley   +1 more source

Efficient Peroral Delivery of Insulin via Vitamin B12 Modified Trimethyl Chitosan Nanoparticles

Journal of Pharmacy & Pharmaceutical Sciences, 2015
PURPOSE: We investigated the effect of vitamin B12 (VB12) modification on the insulin absorption from trimethyl chitosan(TMC) nanoparticles (NPs) under the influence of mucus.
Zhiyang Ke, Han Guo, Xi Zhu, Yun Jin, Yuan Huang   +4 more
doaj   +1 more source

Time Toxicity in Wilms Tumor: Quantifying the Burden of Healthcare Interaction in the First Year After Diagnosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Wilms tumor (WT) treatment imposes a significant time burden on patients and their families. Time toxicity is a patient‐centered metric that quantifies the burden of healthcare interaction. We sought to define time toxicity in the first year after diagnosis of WT and hypothesized that it would increase as tumor stage and treatment ...
Caleb Q. Ashbrook, Veerain Gupta, Nicholas J. Clark, Vijay Rings, Lauren E. Corona, Douglass B. Clayton, Daniel J. Benedetti   +6 more
wiley   +1 more source