Results 21 to 30 of about 770,951 (120)

Efficacy of Intra-Articular Injection of Botulinum Toxin Type A (IncobotulinumtoxinA) in Temporomandibular Joint Osteoarthritis: A Three-Arm Controlled Trial in Rats

Toxins, 2023
Temporomandibular disorders (TMD) are complex pathologies responsible for chronic orofacial pain. Intramuscular injection of botulinum toxin A (BoNT/A) has shown effectiveness in knee and shoulder osteoarthritis, as well as in some TMDs such as ...
Marie Béret, Florent Barry, Maria-Jose Garcia-Fernandez, Henry Chijcheapaza-Flores, Nicolas Blanchemain, Feng Chai, Romain Nicot   +6 more
doaj   +1 more source

Development of α-Tocopherol Succinate-Based Nanostructured Lipid Carriers for Delivery of Paclitaxel

Pharmaceutics, 2022
The management of retinoblastoma (RB) involves the use of invasive treatment regimens. Paclitaxel (PTX), an effective antineoplastic compound used in the treatment of a wide range of malignant tumors, poses treatment challenges due to systemic toxicity ...
Sushrut Marathe, Gauri Shadambikar, Tabish Mehraj, Suresh P. Sulochana, Narendar Dudhipala, Soumyajit Majumdar   +5 more
doaj   +1 more source

Sequential delivery of PD-1/PD-L1 blockade peptide and IDO inhibitor for immunosuppressive microenvironment remodeling via an MMP-2 responsive dual-targeting liposome

Acta Pharmaceutica Sinica B, 2023
Intelligent responsive drug delivery system opens up new avenues for realizing safer and more effective combination immunotherapy. Herein, a kind of tumor cascade-targeted responsive liposome (NLG919@Lip-pep1) is developed by conjugating polypeptide ...
Chuan Hu, Yujun Song, Yiwei Zhang, Siqin He, Xueying Liu, Xiaotong Yang, Tao Gong, Yuan Huang, Huile Gao   +8 more
doaj   +1 more source

Positive-charge tuned gelatin hydrogel-siSPARC injectable for siRNA anti-scarring therapy in post glaucoma filtration surgery

Scientific Reports, 2021
Small interfering RNA (siRNA) therapy is a promising epigenetic silencing strategy. However, its widespread adoption has been severely impeded by its ineffective delivery into the cellular environment.
Yong Yao Chun, Zhu Li Yap, Li Fong Seet, Hiok Hong Chan, Li Zhen Toh, Stephanie W. L. Chu, Ying Shi Lee, Tina T. Wong, Timothy T. Y. Tan   +8 more
doaj   +1 more source

New generation of DNA-based immunotherapy induces a potent immune response and increases the survival in different tumor models

Journal for ImmunoTherapy of Cancer, 2021
Background Strategies to increase nucleic acid vaccine immunogenicity are needed to move towards clinical applications in oncology. In this study, we designed a new generation of DNA vaccines, encoding an engineered vesicular stomatitis virus ...
Alessandra Lopes, Sophie Ligot, Gaëlle Vandermeulen, Chiara Bastiancich, Mathilde Bausart, Laure Lambricht, Kevin Vanvarenberg, Bernard Ucakar, Bernard Gallez   +8 more
doaj   +1 more source

Translation of ionic liquids to be enteric nanoparticles for facilitating oral absorption of cyclosporine A

Bioengineering & Translational Medicine, 2023
Ionic liquids (ILs) attract more and more interests in improving drug transport across membrane, including transdermal, nasal, and oral delivery. However, some drawbacks of ILs impede the application in oral drug delivery, such as rapid precipitation of ...
Kaiheng Liu, Wenjuan Liu, Zirong Dong, Luyu Zhang, Qiuyu Li, Renjie Zhang, Haisheng He, Yi Lu, Wei Wu, Jianping Qi   +9 more
doaj   +1 more source

Cancer DNA vaccines: current preclinical and clinical developments and future perspectives

Journal of Experimental & Clinical Cancer Research, 2019
The recent developments in immuno-oncology have opened an unprecedented avenue for the emergence of vaccine strategies. Therapeutic DNA cancer vaccines are now considered a very promising strategy to activate the immune system against cancer. In the past,
Alessandra Lopes, Gaëlle Vandermeulen, Véronique Préat   +2 more
doaj   +1 more source

An in situ dual-anchoring strategy for enhanced immobilization of PD-L1 to treat autoimmune diseases

Nature Communications, 2023
Immune checkpoints play key roles in maintaining self-tolerance. Targeted potentiation of the checkpoint molecule PD-L1 through in situ manipulation offers clinical promise for patients with autoimmune diseases.
Shenqiang Wang, Ying Zhang, Yanfang Wang, Yinxian Yang, Sheng Zhao, Tao Sheng, Yuqi Zhang, Zhen Gu, Jinqiang Wang, Jicheng Yu   +9 more
doaj   +1 more source

Lyophilized monoclonal antibody (mAb) encoded mRNA—lipid nanoparticles (LNPs) lead to stable in vivo expression of mAb after room temperature storage

AAPS Open
The recent success of mRNA COVID-19 vaccines using lipid nanoparticles (LNPs) underscores the potential of this technology for delivering gene-encoded biologics in humans.
Zimeng Wang, Bei Cheng, Christine Tkaczyk, Michael Newton, Shuolin Cui, Bohdan Andreiuk, Sanjib Saha, Sabrina Khan, Charles Chen, Bin Yang, Adam Gamson, Sarah Siddiqui, George Thom, Antonio DiGiandomenico, Liping Zhou   +14 more
doaj   +1 more source

Multifunctional polymeric micelle-based chemo-immunotherapy with immune checkpoint blockade for efficient treatment of orthotopic and metastatic breast cancer

Acta Pharmaceutica Sinica B, 2019
Immunotherapy has become a highly promising paradigm for cancer treatment. Herein, a chemo-immunotherapy was developed by encapsulating chemotherapeutic drug doxorubicin (DOX) and Toll-like receptor 7 agonist imiquimod (IMQ) in low molecular weight ...
Jiaojie Wei, Yang Long, Rong Guo, Xinlei Liu, Xian Tang, Jingdong Rao, Sheng Yin, Zhirong Zhang, Man Li, Qin He   +9 more
doaj   +1 more source