Results 21 to 30 of about 1,729,749 (314)

Sequential delivery of PD-1/PD-L1 blockade peptide and IDO inhibitor for immunosuppressive microenvironment remodeling via an MMP-2 responsive dual-targeting liposome

Acta Pharmaceutica Sinica B, 2023
Intelligent responsive drug delivery system opens up new avenues for realizing safer and more effective combination immunotherapy. Herein, a kind of tumor cascade-targeted responsive liposome (NLG919@Lip-pep1) is developed by conjugating polypeptide ...
Chuan Hu, Yujun Song, Yiwei Zhang, Siqin He, Xueying Liu, Xiaotong Yang, Tao Gong, Yuan Huang, Huile Gao   +8 more
doaj   +1 more source

Design of hybrid gels based on gellan-cholesterol derivative and P90G liposomes for drug depot applications [PDF]

, 2017
Gels are extensively studied in the drug delivery field because of their potential benefits in therapeutics. Depot gel systems fall in this area, and the interest in their development has been focused on long-lasting, biocompatible, and resorbable ...
Cencetti, Claudia, DI MEO, Chiara, Manca, Maria Letizia, Manconi, Maria, Matricardi, Pietro, Montanari, Elita, Palmieri, Francesca Romana, Zoratto, Nicole   +7 more
core   +2 more sources

A compact targeted drug delivery mechanism for a next generation wireless capsule endoscope [PDF]

, 2016
This paper reports a novel medication release and delivery mechanism as part of a next generation wireless capsule endoscope (WCE) for targeted drug delivery.
Constandinou, TG, Woods, S
core   +2 more sources

Vitamin D3-loaded electrospun cellulose acetate/polycaprolactone nanofibers: Characterization, in-vitro drug release and cytotoxicity studies [PDF]

, 2021
Vitamin D deficiency is nowa global health problem; despite several drug delivery systems for carrying vitaminD due to low bioavailability and loss bioactivity.
Abid, Ahmed, Ali, Amrein, Ardekani, Bagheri, Branton, Bruschi, Chaparro, Chen, Davoodi, Doostan, dos Santos, Glowka, Golizadeh, Grant, Hivechi, Hwang, Iacob, Ilie, Jia, Jiang, Johnson, Joshi, Khoshnevisan, Khoshnevisan, Kohrs, Li, Li, Liang, Liao, Lim, Mahmoodani, Meltzer, Naragund, Nelson, Ng, Nikolac Gabaj, Odusolu, Palacios, Palomba, Pant, Phillips, Phiriyawirut, Phiriyawirut, Pillay, Radisavljevic, Rezk, Sattary, Semnani, Sequeira, Sirc, Stewart, Stewart, Suwantong, Suwantong, Taepaiboon, Tawwab, Temova, Tsai, Tungprapa, Ullah, Ullah, Vatankhah, Wsoo, Wutticharoenmongkol, Xue, Yang, Zamani, Zareie, Zhan, Zhang, Zukowski   +72 more
core   +1 more source

Positive-charge tuned gelatin hydrogel-siSPARC injectable for siRNA anti-scarring therapy in post glaucoma filtration surgery

Scientific Reports, 2021
Small interfering RNA (siRNA) therapy is a promising epigenetic silencing strategy. However, its widespread adoption has been severely impeded by its ineffective delivery into the cellular environment.
Yong Yao Chun, Zhu Li Yap, Li Fong Seet, Hiok Hong Chan, Li Zhen Toh, Stephanie W. L. Chu, Ying Shi Lee, Tina T. Wong, Timothy T. Y. Tan   +8 more
doaj   +1 more source

Nasal Drug Delivery Systems: An Overview [PDF]

, 2015
Since ancient times, drugs have been administered via the nasal route for therapeutic and recreational purposes. The interest in, and importance, of the systemic effects of drugs administered through the nasal route, have expanded over recent decades ...
Conway, Barbara R., Ghori, Muhammad U., Mahdi, Mohammed H., Smith, Alan M.   +3 more
core   +1 more source

Validation of smart nanoparticles as controlled drug delivery systems: loading and pH-dependent release of pilocarpine [PDF]

, 2017
Micelles are good devices for use as controlled drug delivery systems because they exhibit the ability to protect the encapsulated substance from the routes of degradation until they reach the site of action. The present work assesses loading kinetics of
Galbis Fuster, Elsa, Iglesias González, Nieves, Lucas Rodríguez, Ricardo, Muñoz Guerra, Sebastián, Tinajero, Ernesto   +4 more
core   +2 more sources

New generation of DNA-based immunotherapy induces a potent immune response and increases the survival in different tumor models

Journal for ImmunoTherapy of Cancer, 2021
Background Strategies to increase nucleic acid vaccine immunogenicity are needed to move towards clinical applications in oncology. In this study, we designed a new generation of DNA vaccines, encoding an engineered vesicular stomatitis virus ...
Alessandra Lopes, Sophie Ligot, Gaëlle Vandermeulen, Chiara Bastiancich, Mathilde Bausart, Laure Lambricht, Kevin Vanvarenberg, Bernard Ucakar, Bernard Gallez   +8 more
doaj   +1 more source

Multifunctional targeting micelle nanocarriers with both imaging and therapeutic potential for bladder cancer. [PDF]

, 2012
BackgroundWe previously developed a bladder cancer-specific ligand (PLZ4) that can specifically bind to both human and dog bladder cancer cells in vitro and in vivo. We have also developed a micelle nanocarrier drug-delivery system.
de Vere White, Ralph, Gao, Tingjuan, Lam, Kit S, Lara, Primo N, Li, Yuanpei, Lin, Tzu-Yin, Luo, Juntao, Pan, Chong-Xian, Zhang, Hongyong   +8 more
core   +2 more sources

Translation of ionic liquids to be enteric nanoparticles for facilitating oral absorption of cyclosporine A

Bioengineering & Translational Medicine, 2023
Ionic liquids (ILs) attract more and more interests in improving drug transport across membrane, including transdermal, nasal, and oral delivery. However, some drawbacks of ILs impede the application in oral drug delivery, such as rapid precipitation of ...
Kaiheng Liu, Wenjuan Liu, Zirong Dong, Luyu Zhang, Qiuyu Li, Renjie Zhang, Haisheng He, Yi Lu, Wei Wu, Jianping Qi   +9 more
doaj   +1 more source