Results 71 to 80 of about 903,949 (317)

Transfollicular Drug Delivery [PDF]

Pharmaceutical Research, 1995
The hair follicle, hair shaft, and sebaceous gland collectively form what is recognized as the pilosebaceous unit. This complex, three-dimensional structure within the skin possesses a unique biochemistry, metabolism and immunology. Recent studies have focused on the hair follicle as a potential pathway for both localized and systemic drug delivery ...
Lauer, Andrea C., Flynn, Gordon L., Ramachandran, Chandrasekharan, Weiner, Norman D., Lieb, Linda Margaret   +4 more
openaire   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

3D conformation and crystal interaction insights into drug development challenges for HCV drug analogues via molecular simulations

Communications Chemistry
ABT-333 and ABT-072 are two potent non-nucleoside NS5B polymerase inhibitors designed for the treatment of the hepatitis C virus (HCV). These structural analogs differ only by a minor substituent change, which disrupts the planarity of the naphthyl group
Richard S. Hong, Alessandra Mattei, Mark E. Tuckerman, Ahmad Y. Sheikh   +3 more
doaj   +1 more source

Guiding a Diclofenac Sodium Dual-Release Sustained Formulation Development Through In Vitro–In Vivo Relationship Based on Physiologically Based Pharmacokinetics

Pharmaceutics
Background: Dual-release sustained formulations enable rapid drug release for prompt therapeutic onset while retaining the characteristics of sustained-release dosage forms. However, due to the complexity of this dosage form, conventional trial-and-error
Qizheng Wang, Pengcheng Guo, Tianci Hu, Longjie Li, Tingxi Zhu, Yue Pan, Xiaoqiang Xiang, Jianxin Wang   +7 more
doaj   +1 more source

Pharmacokinetic aspects of retinal drug delivery [PDF]

, 2017
Drug delivery to the posterior eye segment is an important challenge in ophthalmology, because many diseases affect the retina and choroid leading to impaired vision or blindness.
Tiina Turunen, Arto Urtti, Bhattacharya, Madhushree, Kari, Otto K., Pelkonen, Laura, Richardson, Dominique, Elisa Toropainen, Madhushree Bhattacharya, Rimpelä, Anna-Kaisa Irmeli, Rimpelä, Anna Kaisa, Marco Casteleijn, Laura Pelkonen, Jaakko Itkonen, Schmitt, Mechthild, Urtti, Arto, Mika Reinisalo, Marika Ruponen, Lajunen, Tatu, Heidi Kidron, Antopolsky, Maxim, Toropainen, Elisa, Casteleijn, Marco; id_orcid, Heikkinen, Emma, Itkonen, Jaakko, del Amo, Eva M., Mechthild Schmitt, Reinisalo, Mika, Dominique Richardson, Emma Heikkinen, Otto K. Kari, Subrizi, Astrid, Anna-Kaisa Rimpelä, Vellonen, Kati Sisko, Casteleijn, Marco G., Kati-Sisko Vellonen, Tatu Lajunen, Turunen, Tiina, Kidron, Heidi, Astrid Subrizi, Eva M. del Amo, Eva Ramsay, Ruponen, Marika, Maxim Antopolsky, Ramsay, Eva, Vellonen, Kati-Sisko, Casteleijn, Marco   +45 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Transmucosal nasal drug delivery : systemic bioavailability of nasally applied midazolam [PDF]

, 2008
Transmucosal nasal drug delivery is a drug delivery option for challenging clinical situations where common drug administrations (e.g., intravenous, intramuscular, or oral) are inapplicable.
Suter-Zimmermann, Katja
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Modulating nuclear stiffness and envelope barrier facilitates AAV nuclear entry and reduces immunogenicity

Nature Communications
Recombinant adeno-associated viruses (rAAVs) have shown promise for orthopedic diseases. However, conventional AAV vectors face major challenges, where immune responses reduce transgene efficacy and inadequate vector potency requires higher doses ...
Yangsen Ou, Fuhua Wu, Chunting He, Shuang Luo, Zhaofei Guo, Yongshun Zhang, Rui Hu, Yanhua Xu, Xue Tang, Yuanhao Zhao, Lin Ye, Xiaoyan Chen, Shuting Bai, Guangsheng Du, Xun Sun   +14 more
doaj   +1 more source