Results 51 to 60 of about 1,809,547 (313)
Advances in Oral Drug Delivery Systems: Challenges and Opportunities
Pharmaceutics, 2023 The oral route is the most preferred route for systemic and local drug delivery. However, the oral drug delivery system faces the harsh physiological and physicochemical environment of the gastrointestinal tract, which limits the bioavailability and ...
Jie Lou +6 more
semanticscholar +1 more source
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Drug DeliveryIschemic stroke represents one of the leading causes of disability and death worldwide. Neuroprotection aimed at mitigating oxidative stress and inflammation is crucial for improving the prognosis of patients.
Jiajia Li +9 more
doaj +1 more source
Intra Vaginal Drug Delivery System (Novel Drug Delivery System)
International Journal for Research in Applied Sciences and Biotechnology, 2020 In case of intra-vaginal route of drug administration the dosage form is applied vaginally for the convenient release of the dosage form and for better therapeutic action of the medicament, it is usually used in HIV patients. many conditions that affect the female reproductive tract, such as , sexually transmitted diseases, fungal & bacterial ...
null Ankit Kumar, null Sanjeev Kumar
openaire +2 more sources
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Cell Death DiscoveryA new type of nonapoptotic, iron-dependent cell death induced by lipid peroxidation is known as ferroptosis. Numerous pathological processes, including inflammation and cancer, have been demonstrated to be influenced by changes in the ferroptosis ...
Shengming Ou +6 more
doaj +1 more source
Application of 7-azaisatins in enantioselective Morita–Baylis–Hillman reaction
Beilstein Journal of Organic Chemistry, 2016 7-Azaisatin and 7-azaoxindole skeletons are valuable building blocks in diverse biologically active substances. Here 7-azaisatins turned out to be more efficient electrophiles than the analogous isatins in the enantioselective Morita–Baylis–Hillman (MBH)
Qing He, Gu Zhan, Wei Du, Ying-Chun Chen
doaj +1 more source
Current Drug Delivery, 2018 Recently, electrospun polymeric nanofibers have proven to be an interesting strategy for drug delivery systems application. The high surface-to-volume ratio of the fibers can improve some processes, such as cell binding and proliferation, drug loading ...
Erick José Torres-Martínez +4 more
semanticscholar +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Marine Drugs, 2023 There is a growing demand for the identification of alternative sources of collagen not derived from land-dwelling animals. The present study explored the use of pepsin- and acid-based extraction protocols to isolate collagen from the swim bladders of ...
Chou Mo +7 more
doaj +1 more source