Design and evaluation of dry-coated tablets for colonic delivery of diclofenac sodium [PDF]
, 2006 A colonic drug delivery system is required to protect a drug during its transit through the upper gastro-intestinal tract and allow its release in the colon.
Gavini, Elisabetta +4 more
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Drug delivery in overcoming the blood-brain barrier: role of nasal mucosal grafting [PDF]
, 2017 The blood–brain barrier (BBB) plays a fundamental role in protecting and maintaining the homeostasis of the brain. For this reason, drug delivery to the brain is much more difficult than that to other compartments of the body. In order to bypass or cross
Carafa, Maria +5 more
core +1 more source
Advanced Science, 2021 Mitochondria are highly involved in the metastasis of cancer cells. However, low permeability of mitochondria impedes the entry of anti‐cancer drugs. Here, a self‐assembled nanoparticle platform is designed that not only targets the DNA‐intercalating ...
Xi Lin +6 more
doaj +1 more source
Iontophoresis - estimating the released drug [PDF]
, 2015 The use of enhancers to increase the drug molecules penetration into target tissues is an usual technique in drug delivery. In transdermal drug delivery, electric fields are often used to increase the drug transport to the target tissue. In this paper we
Ferreira, José Augusto
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Hydrogen-bonded multilayer thin films and capsules based on poly(2-n-propyl-2-oxazoline) and tannic acid : investigation on intermolecular forces, stability, and permeability [PDF]
, 2019 In recent years, hydrogen-bonded multilayer thin films and capsules based on neutral and nontoxic building blocks have been receiving interest for the design of stimuli-responsive drug delivery systems and for the preparation of thin-film coatings ...
Hoogenboom, Richard +5 more
core +1 more source
Knowledge-guided diffusion model for 3D ligand-pharmacophore mapping
Nature CommunicationsPharmacophores are abstractions of essential chemical interaction patterns, holding an irreplaceable position in drug discovery. Despite the availability of many pharmacophore tools, the adoption of deep learning for pharmacophore-guided drug discovery ...
Jun-Lin Yu +9 more
doaj +1 more source
Drug Delivery, 2018 An estrogen (ES)-functionalized cationic liposomal system was developed and exploited for targeted delivery to osteosarcoma. Natural biocompatible chotooligosaccharides (COS, MW2-5 KDa) were covalently tethered to the liposomal surface through a ...
Xuelei Yin +6 more
doaj +1 more source
Design of a Drug Delivery System through the Gastrointestinal Tract [PDF]
, 2016 Alzheimer’s Disease (AD) afflicts an estimated 5.3 million individuals and is the sixth leading cause of death in America. The drug delivery method of interest is an orally administered sustained-release delivery system that addresses the needs of the ...
Chen, Kaixin +3 more
core +2 more sources
Genome-wide transcription analysis of interaction between the human macrophage and Mycobacterium tuberculosis during concurrent drug administration by conventional and novel methods [PDF]
, 2008 Targeted drug delivery to alveolar macrophages harboring Mycobacterium tuberculosis (Mtb) holds promise of high efficacy against pulmonary tuberculosis (TB).
Amit K. Singh +2 more
core +2 more sources
Core/shell microencapsulation of indomethacin/paracetamol by co-axial electrohydrodynamic atomization [PDF]
, 2017 Core/shell microparticles for development of drug delivery systems were prepared using co-axial electrohydrodynamic atomization technique in order to develop fixed dose combined formulations incorporating paracetamol and indomethacin as model drugs.
Edirisinghe, M +4 more
core +1 more source