Results 21 to 30 of about 779,180 (303)

Enhancement of Oxytocin in the Medial Prefrontal Cortex Reverses Behavioral Deficits Induced by Repeated Ketamine Administration in Mice

Frontiers in Neuroscience, 2021
Ketamine is a popular recreational substance of abuse that induces persistent behavioral deficits. Although disrupted oxytocinergic systems have been considered to modulate vulnerability to developing drugs of abuse, the involvement of central oxytocin ...
Weili Zhu, Zengbo Ding, Zhihui Zhang, Xiao Wu, Xiaoya Liu, Ya Zhang, Suxia Li, Liping Zhou, Geng Tian, Jing Qin   +9 more
doaj   +1 more source

Novel psychoactive substance use by mental health service consumers: an online survey of inpatient health professionals’ views and experiences [PDF]

, 2017
Purpose: There is evidence that novel psychoactive substances (NPS) are commonly used by people with severe mental illness. The aim of the study was to undertake a scoping survey to explore inpatient mental health workers' perceptions of NPS use by ...
Clinical Guidelines on Drug Misuse and Dependence Update 2017 Independent Expert Working Group, Department of Health, European Monitoring Centre for Drugs and Drug Addiction, European Monitoring Centre for Drugs and Drug Addiction (EMCDDA), IBM   +4 more
core   +1 more source

Impact of Chronic Alcohol and Opioid Dependence on Biochemical Parameters: A Retrospective Case Control Study from a Tertiary Care Treatment Center in North India [PDF]

Addiction and Health, 2021
Background: Assessment of biochemical parameters can help in the comprehensive management of patients with substance use disorders (SUDs). The aim of this study was to analyse the biochemical parameters of patients with alcohol and opioid dependence at ...
Rizwana Quraishi, Siddharth Sarkar, Raka Jain   +2 more
doaj   +1 more source

AMPK signaling in the nucleus accumbens core mediates cue-induced reinstatement of cocaine seeking

Scientific Reports, 2017
Relapse to drug seeking can be caused by exposure to drug-associated cues, provoking drug craving even after prolonged abstinence. Recent studies demonstrated that AMP-activated protein kinase (AMPK) regulates neuronal morphology and membrane ...
Xue-Jiao Gao, Kai Yuan, Lu Cao, Wei Yan, Yi-Xiao Luo, Min Jian, Jian-Feng Liu, Qin Fang, Ji-Shi Wang, Ying Han, Jie Shi, Lin Lu   +11 more
doaj   +1 more source

Effects of 3-methylmethcathinone on conditioned place preference and anxiety-like behavior: Comparison with methamphetamine

Frontiers in Molecular Neuroscience, 2022
3-Methylmethcathinone (3-MMC), a drug belonging to synthetic cathinones family, raised public attention due to its harmful health effects and abuse potential.
Yang Chen, Yang Chen, Libo Zhang, Libo Zhang, Zengbo Ding, Xianwen Wu, Guibin Wang, Jie Shi, Jie Shi, Jie Shi   +9 more
doaj   +1 more source

Molecular Mechanisms Associated with Nicotine Pharmacology and Dependence. [PDF]

, 2020
Tobacco dependence is a leading cause of preventable disease and death worldwide. Nicotine, the main psychoactive component in tobacco cigarettes, has also been garnering increased popularity in its vaporized form, as derived from e-cigarette devices ...
A Ashoor, A Kuryatov, A Loukola, A Loukola, A Markou, A Pandhare, AA George, AA Strasser, AB Tekinay, AC Harris, AC Villanti, AJ Lanca, AJ Law, AK Stoker, AR Tapper, AT Peana, B Forget, B Froeliger, B Le Foll, B Lenz, BJ Hall, BJ Henderson, CD Fowler, CD Fowler, CDC, CJ Livingston, CL Walters, CL Walters, CM Flores, D Bagdas, D Carmelli, D Gonzales, D Ji, D John, D Vullhorst, DB Vazquez-Sanroman, DC Perry, DK Williams, E Wada, EC Pittaras, ED Claus, EE DeVito, EJ Nestler, EN Lyukmanova, FI Carroll, FJ McClernon, G Di Chiara, G Kong, G Schoenbaum, GS Portugal, H Xian, HD Mansvelder, I Ibanez-Tallon, J Hartmann-Boyce, J Hartmann-Boyce, J Ramirez-Latorre, J Tang, JA Dani, JA Dani, JA Hill Jr, JA Wilking, JE Lisman, JJ Couey, JM Miwa, JM Miwa, JM Miwa, JM Williams, JP Changeux, JR Turner, JR Turner, JR Turner, JS Fowler, JS Fowler, JW Kenney, JZ Liu, KA Garrison, KJ Clemens, KJ Jackson, KJ Jackson, KJ Jackson, KJ Jackson, KP Cosgrove, KS Kendler, KS Okuyemi, L Lagostena, L Zhou, LJ Bierut, LM Tuesta, LP Dwoskin, LP Dwoskin, M Alkondon, M Alkondon, M Arvaniti, M De Biasi, M Foddai, M Kallupi, M Kassiou, M Yuan, M Zhang, MD Li, MI Damaj, MJ Marks, MJ Orejarena, ML Fisher, ML Goniewicz, MP Demars, MR Picciotto, MS Thomsen, MT Bardo, N Champtiaux, N Omelchenko, NI Nissen, NL Benowitz, NL Saccone, O Salminen, P Fagan, P Li, P Truman, PF Sullivan, PJ Welsby, R Girod, R Klink, R Miech, R Salas, R Srinivasan, RL Ashare, RS Caraballo, S Dodd, S Jones, S Kuhn, S Nakauchi, S Pons, S Tonstad, SD Alsharari, SD Alsharari, SS Sanjakdar, TT Smith, U Broms, U Maskos, V Gerzanich, W Berrettini, WA Corrigall, WD Myers, X Pang, Y Li, YY Huang, Z Jin   +146 more
core   +1 more source

Systems analysis of drug-induced receptor tyrosine kinase reprogramming following targeted mono- and combination anti-cancer therapy [PDF]

, 2014
The receptor tyrosine kinases (RTKs) are key drivers of cancer progression and targets for drug therapy. A major challenge in anti-RTK treatment is the dependence of drug effectiveness on co-expression of multiple RTKs which defines resistance to single ...
Bown, James L., Deeni, Yusuf Y., Goltsov, Alexey, Harrison, David J., Hu, Huizhong, Khalil, Hilal S., Kyriakidis, Stylianos, Langdon, Simon P., Soininen, Tero   +8 more
core   +6 more sources

An overview of mechanisms underlying the comorbidity of sleep and depression disorders in the elderly

Stress and Brain
Sleep disruption is common in older adults and has been linked to many negative health outcomes, including impaired cognitive, emotional, and interpersonal functioning and maladaptive metabolic changes.
Yuan Yao, Dan Guo, Fang-Lin Liu, Ying Han   +3 more
doaj   +1 more source

Evaluation of a training workshop on tobacco cessation: capacity building initiative in India

Tobacco Induced Diseases, 2018
Background The World Health Organization's (WHO) Tobacco Free Initiative highlights the role of health care professionals such as nurses, pharmacists, counselors and related support staff, in implementing smoking-cessation services.
Sonali Jhanjee, Mohit Kumar Varshney, Udit Kumar Panda, Gauri Shanker Kaloiya, Prabhu Dayal, Deepak Yadav   +5 more
doaj   +1 more source

The relationship between severity of drug problems and perceived interdependence of drug use and sexual intercourse among adult males in drug addiction rehabilitation centers in Japan

Substance Abuse Treatment, Prevention, and Policy, 2021
Background Consuming drugs in conjunction with sexual intercourse may shape the perceived interdependence of drug use and sexual intercourse (PIDS). Additionally, the severity of drug problems may have a significant impact on PIDS.
Risa Yamada, Takuya Shimane, Ayumi Kondo, Masako Yonezawa, Toshihiko Matsumoto   +4 more
doaj   +1 more source