Results 211 to 220 of about 17,208,238 (361)

Microemulsion systems: from the design and architecture to the building of a new delivery system for multiple-route drug delivery

, 2020
Eryvaldo Sócrates Tabosa do Egito, Lucas Amaral-Machado, Éverton do Nascimento Alencar, Anselmo Gomes de Oliveira   +3 more
openalex   +2 more sources

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Conquering viral drug resistance: Structural and mechanistic paradigms for antiresistance drug design. [PDF]

Pharm Sci Adv
Wang M, Jia H, Liu X, Zhan P.
europepmc   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Medicinal chemistry perspectives on anticancer drug design based on clinical applications (2015-2025). [PDF]

RSC Adv
Al-Karmalawy AA, Eissa ME, Ashour NA, Yousef TA, Al Khatib AO, Hawas SS.   +5 more
europepmc   +1 more source

Review of: "Thiazole Schiff Bases as Potential Breast Cancer Drugs through Design, Synthesis, and In Silico Analysis" [PDF]

Danuta Branowska
openalex   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Is Mycobacterial InhA a Suitable Target for Rational Drug Design? [PDF]

ChemMedChem
Rizet J, Maveyraud L, Rengel D, Guillet V, Publicola G, Rodriguez F, Lherbet C, Mourey L.   +7 more
europepmc   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Computer-Aided Drug Design Across Breast Cancer Subtypes: Methods, Applications and Translational Outlook. [PDF]

Int J Mol Sci
Tian W, Hu Y, Gao X, Yang J, Jiang W.
europepmc   +1 more source