Results 151 to 160 of about 2,218,427 (310)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Strategies for the drug development of cancer therapeutics. [PDF]

Front Pharmacol
Liu H, Ma Y, Chen W, Gu X, Sun J, Li P.
europepmc   +1 more source

Figure S3 from Development of a Novel DNA Mono-alkylator Platform for Antibody–Drug Conjugates

Joshua D. Thomas, Aleksandr V. Yurkovetskiy, Mao Yin, Natalya D. Bodyak, Shuyi Tang, Marina Protopopova, Eugene Kelleher, Brian Jones, Liping Yang, Daniel Custar, Kalli C. Catcott, Damon R. Demady, Scott D. Collins, Ling Xu, Charlie Bu, LiuLiang Qin, Elena Ter‐Ovanesyan, Marc Damelin, Dorin Toader, Timothy B. Lowinger   +19 more
openalex   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Experimental Models and Translational Strategies in Neuroprotective Drug Development with Emphasis on Alzheimer's Disease. [PDF]

Molecules
Niziński P, Szalast K, Makuch-Kocka A, Paruch-Nosek K, Ciechanowska M, Plech T.   +5 more
europepmc   +1 more source

The importance of genotoxicity tests in new drug development process<p>Genotoksisite testlerinin yeni ilaç geliştirme sürecindeki önemi

, 2018
Selen Şen, Ayfer Beceren, Hüseyin Aksoy   +2 more
openalex   +2 more sources

History, current trends and prospects for the development of pro- and prebiotic drugs in Russia and abroad

, 2022
Yu. S. Savinova, N. L. Belkova, Н. В. Семенова, Л. В. Рычкова   +3 more
openalex   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Drug Development [PDF]

JAMA, 2004
openaire   +2 more sources

In Silico Clinical Trials in Drug Development: A Systematic Review. [PDF]

Ther Innov Regul Sci
Chen B, Schneider LC, Röver C, Comets E, Elze MC, Hooker A, IntHout J, Jannot AS, Julkowska D, Mimouni Y, Savelieva M, Stallard N, Ursino M, Vandemeulebroecke M, Weber S, Posch M, Zohar S, Friede T.   +17 more
europepmc   +1 more source