Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Drug Development Strategy in the United States: An Industrial View of DMPK
, 2021 Joseph W. Polli
openalex +2 more sources
The development impact of the illegality of drug trade [PDF]
This paper reviews the unintended consequences of the war on drugs, particularly for developing countries, and weighs them against the evidence regarding the efficacy of prohibition to curb drug use and trade.
Keefer, Philip +2 more
core
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
Alternative buffer systems in biopharmaceutical formulations and their effect on protein stability
Acta PharmaceuticaThe formulation of biopharmaceutical drugs is designed to eliminate chemical instabilities, increase conformational and colloidal stability of proteins, and optimize interfacial stability. Among the various excipients involved, buffer composition plays a
Lebar Blaž +5 more
doaj +1 more source
Tribo-electrification and Powder Adhesion Studies in the Development of Polymeric Hydrophilic Drug Matrices [PDF]
, 2015 Muhammad Usman Ghori +2 more
openalex +1 more source
Industry Perspectives in Modern Drug Research and Development Strategies
, 2021 Tamás Shisha, P Gergely
openalex +2 more sources
Antibacterial Drug Development: A New Approach Is Needed for the Field to Survive and Thrive [PDF]
, 2020 M. Courtney Safir +4 more
openalex +1 more source
Molecular Oncology, EarlyView.Using multi‐omic characterization, we aimed to identify key regulators specific to squamous cell lung carcinoma (SqCC). SqCC‐specific differentially expressed genes were integrated with metabolics data. High expression of the creatine transporter SLC6A8, along with elevated creatine levels, appeared to be a distinct metabolic feature of SqCC.
Johan Staaf +10 more
wiley +1 more source
Development of human iPSC-derived cardiomyocytes-based heart-on-a-chip with customized multi-electrode array for drug-induced cardiotoxicity evaluations [PDF]
Geonho Choi +10 more
openalex +1 more source