Results 221 to 230 of about 2,218,427 (310)

Expediting Drug Development in Japan: A PMDA Perspective. [PDF]

Clin Pharmacol Ther
Kohno Y, Ishiguro A, Yasukawa T, Yasuda N, Tanaka D, Araki Y, Takahashi Y, Uyama Y, Fujiwara Y.   +8 more
europepmc   +1 more source

Development of curcumin formulations with enhanced bioavailability for oral drug delivery

, 2018
Yishan Zheng, Ananth Sekher Pannala, Tu Duong Ngoc, John Smart   +3 more
openalex   +2 more sources

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

A Generalized Minimal PBPK-PD Model of Bispecific Antibodies: Case Studies and Applications in Drug Development. [PDF]

CPT Pharmacometrics Syst Pharmacol
Spinosa P, Joslyn L, Ramanujan S, Gadkar K, Hosseini I.   +4 more
europepmc   +1 more source

Part III: Metabolic bone disease: Recent developments in the pathogenesis of endocrine-, drug-, genetic-, renal-, HIV-, and malignancy-induced bone disease [PDF]

, 2009
EJ Raubenheimer
openalex  

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Co-regulation of microglial subgroups in Alzheimer's amyloid pathology: Implications for diagnosis and drug development. [PDF]

PLoS One
Zhou Y, Huang Y, Fan Y, Xue F.
europepmc   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Molecular Basis of GABA Aminotransferase Inhibition in Epilepsy: Structure, Mechanisms, and Drug Development. [PDF]

Curr Issues Mol Biol
Yasir M, Choe J, Han JH, Chun W.
europepmc   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source