Results 231 to 240 of about 2,218,427 (310)

Exploring Artificial Intelligence's Potential to Enhance Conventional Anticancer Drug Development. [PDF]

Drug Dev Res
Bobolea SȘ, Hinoveanu MI, Dimitriu A, Brașoveanu MA, Iliescu CN, Dinu-Pîrvu CE, Ghica MV, Anuța V, Popa L, Prisada RM.   +9 more
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Impact of Model-Informed Drug Development on Drug Development Cycle Times and Clinical Trial Cost. [PDF]

Clin Pharmacol Ther
Sahasrabudhe V, Nicholas T, Nucci G, Musante CJ, Corrigan B.   +4 more
europepmc   +1 more source

Toxicity profile analysis of compound 6e insights from ADMET “SAR” predictions for safer drug development.

Yasser Hussein Issa Mohammed (17140711), Ahmed Hassen Shntaif (22320292), Saad Alghamdi (362506), Ahd A. Mansour (21660692), Naeem F. Qusty (15416890), Azhar S. Sindi (13259916), Ahmad O. Babalghith (15279713), Ghazi A. Bamagous (22320295), Eman Adnan Abu-Seer (22320298)   +8 more
openalex   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

The Advance of In Silico Evidence to Transform Pediatric Drug Development for Rare Diseases. [PDF]

CPT Pharmacometrics Syst Pharmacol
Knöchel J, Zhao P, Desikan R, Zhou J, Abrantes JA, Harnisch L.   +5 more
europepmc   +1 more source

Recent Developments in Drug Discovery: From Artificial Intelligence to Targeted Protein Degradation

B. R. Arun Kumar
openalex   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source