Results 241 to 250 of about 2,218,427 (310)

Generation and characterisation of a humanised GLP-1 receptor mouse model for translational drug development. [PDF]

EBioMedicine
Sonne N, Roque M, Zachariassen LF, Porsgaard T, Pors SE, Cavalera M, Jones C, Osborn O, Thorbek DD, Riis ML, Feigh M, Quinn K, Gaidarov I, Anthony T, Hansen HH, Tozzi M.   +15 more
europepmc   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Correction: Anticancer drug development against ribosome synthesis and the nucleolus. [PDF]

Biochem Soc Trans
Loiacono A, Huang S.
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Genetic Variations in the P2X7 Receptor: Opportunities and Challenges for Drug Development. [PDF]

Int J Mol Sci
Cheah JSY, Skarratt KK, Fuller SJ, Balle T.   +3 more
europepmc   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Genetic evidence informs the direction of therapeutic modulation in drug development. [PDF]

NPJ Drug Discov
Chen R, Duffy Á, Park JK, Stein D, Schlessinger A, Itan Y, Glicksberg BS, Tinker RJ, Jordan DM, Rocheleau G, Do R.   +10 more
europepmc   +1 more source

Iridium-Catalyzed CH-Functionalization : Development and Applications of Innovative Strategies for Hydrogen Isotope Exchange on Small Molecules and Biotherapeutic Drugs for Drug Discovery

, 2020
Mégane Valero
openalex   +1 more source

Harnessing Organoid Platforms for Nanoparticle Drug Development. [PDF]

Drug Des Devel Ther
Chen L, Luo X, Zhang J, Zhang J, Yang C, Zhao Y.   +5 more
europepmc   +1 more source