Results 261 to 270 of about 21,426,149 (319)

Revising NHE-1: From Cardiac Homeostasis to Heart Failure and Future Drug Development. [PDF]

Cell Biochem Funct
Bouratzis V, Douskou N, Tzavellas NP, Simos YV, Bozidis P, Tsamis KI, Markopoulos GS, Peschos D, Lakkas L.   +8 more
europepmc   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Recommendations for the use of clinical outcome assessments in rare disease drug development. [PDF]

EClinicalMedicine
Aiyegbusi OL, McCorry NK, Calvert MJ, Peipert JD, Rivera SC, Muni-Lofra R, Alexis S, Awan F, Bailey T, Billingham L, Callaghan R, Collins C, Currie BM, Dixon M, Duddridge M, Ennis J, Fred L, Greenwell S, Griffiths C, Hareendran A, Illoh OA, Leeson-Beevers K, Letchemanan K, Lister SP, McCabe C, McFatrich M, McKnight AJ, McLaughlin F, Moldovan R, Murray LT, O'Connor DJ, Oko-Osi H, Oni L, Pritchard KM, Rantell KR, Straub V, Barrett TG, LifeArc Accelerating Rare Disease Trials (ARDT) centreaf, LifeArc Accelerating Rare Disease Trials (ARDT) centre.   +38 more
europepmc   +1 more source

Drugs in developing countries

BMJ, 1986
openaire   +3 more sources

Optimising patient centred drug development to realise impact. [PDF]

Commun Med (Lond)
Calvert M, Kamudoni P, Yap C, Snyder C, Wilson R, Aiyegbusi OL.   +5 more
europepmc   +1 more source

Computational Methods in Drug Development: From Molecular Modeling to Artificial Intelligence Technologies. [PDF]

Pharmaceuticals (Basel)
Zhao Y.
europepmc   +1 more source

Cancer Cachexia Research and Drug Development: Lessons from Failures and the Promise of Immunomodulation. [PDF]

Cancers (Basel)
Zhang L, Norton JA.
europepmc   +1 more source

Development of a Translational Assay for Identification and Quantitation of Orthologous Proteins to Aid Drug Development in Preclinical Models. [PDF]

J Proteome Res
Rougemont B, Borgel J, Walker Z, Zubiri I, O'Cualain R, Ali Mohammadi Nafchi N, Shaw CE, Sirka E, Isaac J, Miranda CJ, Ettorre A.   +10 more
europepmc   +1 more source