Results 281 to 290 of about 2,491,987 (318)
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Drug Development and Regulation
Medicine, 2003Abstract Models of drug development are moving away from those traditionally represented by large multinational pharmaceutical companies. The reasons for this trend and the likely shape of the pharmaceutical industry of the future are discussed here.
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2012 9th IEEE International Symposium on Biomedical Imaging (ISBI), 2012
Positron emission tomography (PET) is a tomographic imaging technique that allows for accurate non-invasive in vivo measurements of regional tissue function in man. It is the most selective and sensitive imaging modality able to measure molecular pathways and interactions in vivo at a picomolar level.
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Positron emission tomography (PET) is a tomographic imaging technique that allows for accurate non-invasive in vivo measurements of regional tissue function in man. It is the most selective and sensitive imaging modality able to measure molecular pathways and interactions in vivo at a picomolar level.
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Drug development in neuropsychopharmacology
European Archives of Psychiatry and Clinical Neuroscience, 2008Personalized medicine is still in its infancy concerning drug development in neuropsychopharmacology. Adequate biomarkers with clinical relevance to drug response and/or tolerability and safety largely remain to be identified. Possibly, this kind of personalized medicine will first gain clinical relevance in the dementias. The clinical relevance of the
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Radiotracers in Drug Development
2006Although there are numerous books on drug metabolism, Radiotracers in Drug Development is unique in explaining how radiotracers are used to elucidate a drug’s absorption, distribution, metabolism, and excretion (ADME). Covering traditional and recent technologies and applications, the book takes a strong industrial approach, discussing the basics of ...
Graham Lappin, Simon Temple
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Active drug metabolites in drug development
Current Opinion in Pharmacology, 2003Active drug metabolites discovered during the course of drug development constitute a subset of the larger issue of metabolic drug interactions, but still demand unique consideration from both an efficacy and a safety point of view. Improved technology has allowed better identification and quantification of metabolites, raising new issues to be ...
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Antipsychotic Drug Development
2010Schizophrenia typically manifests itself with a wide array of symptoms--positive, negative, cognitive, and affective--and may also involve neurodevelopmental and neurodegenerative aspects. Each of these symptom dimensions may be derived from pathology at one or more receptor types, localized in different regions of the brain.
Dennis H, Kim, Stephen M, Stahl
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2015
Imaging has played an important part in the diagnosis of disease and development of the understanding of the underlying disease mechanisms and is now poised to make an impact in the development of new pharmaceuticals. This chapter discusses the underlying technologies that make the field ready for this challenge.
James, Nairne +2 more
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Imaging has played an important part in the diagnosis of disease and development of the understanding of the underlying disease mechanisms and is now poised to make an impact in the development of new pharmaceuticals. This chapter discusses the underlying technologies that make the field ready for this challenge.
James, Nairne +2 more
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2019
Allosteric regulation is a ubiquitous strategy employed in nature to control cellular processes by regulating the affinities of biomolecules. Allosteric modulators are able to tune the protein/substrate affinity in a highly predictable way, suggesting that such modulators may represent safe drugs.
Xi, Cheng, Hualiang, Jiang
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Allosteric regulation is a ubiquitous strategy employed in nature to control cellular processes by regulating the affinities of biomolecules. Allosteric modulators are able to tune the protein/substrate affinity in a highly predictable way, suggesting that such modulators may represent safe drugs.
Xi, Cheng, Hualiang, Jiang
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Antibody–drug conjugates: Smart chemotherapy delivery across tumor histologies
Ca-A Cancer Journal for Clinicians, 2022Paolo Tarantino +2 more
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Targeted drug delivery strategies for precision medicines
Nature Reviews Materials, 2021Mandana T Manzari +2 more
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